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[局限性前列腺癌治疗中的当前争议]

[Current controversies in the treatment of localized prostate cancer].

作者信息

Bischoff R, Chaloupka M, Westhofen T, Grimm T, Schlenker B, Weinhold P, Tilki D, Stief C G, Kretschmer A

机构信息

Urologische Klinik und Poliklinik, Klinikum der Universität München, Marchioninistraße 15, 81377, München, Deutschland.

Martini-Klinik Prostatakarzinomzentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.

出版信息

Urologe A. 2019 May;58(5):524-528. doi: 10.1007/s00120-019-0903-8.

DOI:10.1007/s00120-019-0903-8
PMID:30859231
Abstract

In the prostate-specific antigen (PSA) era, most prostate cancers (PCa) are diagnosed in a localized stage and a plethora of therapeutic options are warranted in different clinical settings and disease stages of localized PCa. In the current narrative review, we give an overview of the current controversies in the therapeutic landscape of localized PCa and focus on organ-sparing approaches, percutaneous radiotherapy, brachytherapy as well as retropubic and robot-assisted prostatectomy by summarizing studies that have been published within the last two years.

摘要

在前列腺特异性抗原(PSA)时代,大多数前列腺癌(PCa)在局部阶段被诊断出来,在局限性PCa的不同临床环境和疾病阶段有大量的治疗选择。在当前的叙述性综述中,我们概述了局限性PCa治疗领域当前的争议,并通过总结过去两年内发表的研究,重点关注保留器官的方法、经皮放疗、近距离放疗以及耻骨后和机器人辅助前列腺切除术。

相似文献

1
[Current controversies in the treatment of localized prostate cancer].[局限性前列腺癌治疗中的当前争议]
Urologe A. 2019 May;58(5):524-528. doi: 10.1007/s00120-019-0903-8.
2
[Prostatectomy, brachytherapy, percutaneous irradiation. Which method helps your patients the most?].
MMW Fortschr Med. 2002 Jan 17;144(1-2):39-41.
3
Brachytherapy or radical prostatectomy: is there a preferred method for treating localized prostate cancer?
BJU Int. 2004 Jan;93(1):5. doi: 10.1111/j.1464-410x.2004.04544.x.
4
Salvage low-dose-rate brachytherapy for prostate cancer local recurrence after radical prostatectomy: our first three patients.挽救性低剂量率近距离放射治疗用于根治性前列腺切除术后前列腺癌局部复发:我们的前三例患者
Urologia. 2014 Jan-Mar;81(1):46-50. doi: 10.5301/urologia.5000034. Epub 2013 Nov 28.
5
[Multidisciplinary approach in the treatment of localized forms of cancer of the prostate].[前列腺局限性癌治疗中的多学科方法]
Cancer Radiother. 2000 Nov;4 Suppl 1:105s-108s.
6
Prostate specific antigen only progression of prostate cancer.仅前列腺特异性抗原进展的前列腺癌。 (此译文表述稍显生硬,原英文表述可能不太准确规范,更准确的翻译或许是“前列腺癌仅表现为前列腺特异性抗原进展” )
J Urol. 2000 Jun;163(6):1632-42.
7
Brachytherapy and radical prostatectomy in patients with early prostate cancer.早期前列腺癌患者的近距离放射治疗和根治性前列腺切除术
Rev Assoc Med Bras (1992). 2015 Sep-Oct;61(5):431-9. doi: 10.1590/1806-9282.61.05.431.
8
Radiation therapy for prostate cancer increases subsequent risk of bladder and rectal cancer: a population based cohort study.前列腺癌放射治疗会增加后续患膀胱癌和直肠癌的风险:一项基于人群的队列研究。
J Urol. 2008 Nov;180(5):2005-9; discussion 2009-10. doi: 10.1016/j.juro.2008.07.038. Epub 2008 Sep 17.
9
[Advancement of treatment for prostate cancer].[前列腺癌治疗的进展]
Gan To Kagaku Ryoho. 2006 Feb;33(2):178-82.
10
Low-dose-rate brachytherapy as salvage treatment of local prostate cancer recurrence after radical prostatectomy.低剂量率近距离放射治疗作为根治性前列腺切除术后局部前列腺癌复发的挽救治疗。
Urology. 2011 Jun;77(6):1416-9. doi: 10.1016/j.urology.2011.02.011. Epub 2011 Apr 13.

本文引用的文献

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Medium-term oncological outcomes in a large cohort of men treated with either focal or hemi-ablation using high-intensity focused ultrasonography for primary localized prostate cancer.高强度聚焦超声治疗局限性前列腺癌的大样本聚焦或半切除治疗患者的中期肿瘤学结果。
BJU Int. 2019 Sep;124(3):431-440. doi: 10.1111/bju.14710. Epub 2019 Mar 18.
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SPCG-15: a prospective randomized study comparing primary radical prostatectomy and primary radiotherapy plus androgen deprivation therapy for locally advanced prostate cancer.SPCG - 15:一项比较局部晚期前列腺癌的根治性前列腺切除术与根治性放疗加雄激素剥夺治疗的前瞻性随机研究。
Scand J Urol. 2018 Oct-Dec;52(5-6):313-320. doi: 10.1080/21681805.2018.1520295. Epub 2018 Dec 26.
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Surgery vs Radiotherapy in the Management of Biopsy Gleason Score 9-10 Prostate Cancer and the Risk of Mortality.
手术与放疗在处理活检前列腺癌评分 9-10 级及死亡率风险中的比较。
JAMA Oncol. 2019 Feb 1;5(2):213-220. doi: 10.1001/jamaoncol.2018.4836.
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Comparative Effectiveness of Radical Prostatectomy Versus External Beam Radiation Therapy Plus Brachytherapy in Patients with High-risk Localized Prostate Cancer.高危局限性前列腺癌患者行根治性前列腺切除术与外照射放疗联合近距离治疗的疗效比较。
Eur Urol. 2019 Apr;75(4):552-555. doi: 10.1016/j.eururo.2018.10.032. Epub 2018 Nov 10.
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Focal therapy in localised prostate cancer: Real-world urological perspective explored in a cross-sectional European survey.局限性前列腺癌的聚焦治疗:一项欧洲横断面调查中探讨的现实世界泌尿外科视角
Urol Oncol. 2018 Dec;36(12):529.e11-529.e22. doi: 10.1016/j.urolonc.2018.08.013. Epub 2018 Oct 6.
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Initial toxicity, quality-of-life outcomes, and dosimetric impact in a randomized phase 3 trial of hypofractionated versus standard fractionated proton therapy for low-risk prostate cancer.低危前列腺癌大分割质子治疗与标准分割质子治疗随机3期试验中的初始毒性、生活质量结果及剂量学影响
Adv Radiat Oncol. 2018 Feb 23;3(3):322-330. doi: 10.1016/j.adro.2018.02.004. eCollection 2018 Jul-Sep.
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Randomized Trial of Hypofractionated, Dose-Escalated, Intensity-Modulated Radiation Therapy (IMRT) Versus Conventionally Fractionated IMRT for Localized Prostate Cancer.随机分组试验:低分割、剂量递增、强度调制放射治疗(IMRT)对比常规分割 IMRT 治疗局限性前列腺癌。
J Clin Oncol. 2018 Oct 10;36(29):2943-2949. doi: 10.1200/JCO.2018.77.9868. Epub 2018 Aug 14.
8
Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: 24-month outcomes from a randomised controlled study.机器人辅助腹腔镜前列腺切除术与开放经耻骨后前列腺根治术的比较:一项随机对照研究的 24 个月结果。
Lancet Oncol. 2018 Aug;19(8):1051-1060. doi: 10.1016/S1470-2045(18)30357-7. Epub 2018 Jul 17.
9
A Multicentre Study of 5-year Outcomes Following Focal Therapy in Treating Clinically Significant Nonmetastatic Prostate Cancer.多中心研究:5 年随访结果显示,局灶性治疗对有临床意义的非转移性前列腺癌的疗效。
Eur Urol. 2018 Oct;74(4):422-429. doi: 10.1016/j.eururo.2018.06.006. Epub 2018 Jun 28.
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Medium-term Follow-up of Vascular-targeted Photodynamic Therapy of Localized Prostate Cancer Using TOOKAD Soluble WST-11 (Phase II Trials).局部前列腺癌的血管靶向光动力疗法的中期随访:使用 TOOKAD 可溶性 WST-11(II 期试验)。
Eur Urol Focus. 2019 Nov;5(6):1022-1028. doi: 10.1016/j.euf.2018.04.003. Epub 2018 Apr 13.