Derinöz-Güleryüz Okşan
Department of Pediatric Emergency, Gazi University Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr. 2018;60(4):439-442. doi: 10.24953/turkjped.2018.04.015.
Derinöz-Güleryüz O. Doxylamine succinate overdose: Slurred speech and visual hallucination. Turk J Pediatr 2018; 60: 439-442. Doxylamine succinate is a commonly used antihistamine for respiratory allergies including allergic rhinitis as well as for the management of insomnia. As it is available over-the-counter like other nonprescription antihistamines and sleep aids, there is a risk of overdose. It is believed that doxylamine succinate has both peripheral and central activity with its anticholinergic properties. Delirium, seizures, and coma are among the central adverse effects that are rare. This case was presented since it is the first case in the literature who developed slurred speech and visual hallucination after high dose doxylamine succinate use and received antidotal therapy for anticholinergic side effects.
德林奥兹-居勒吕兹·O. 琥珀酸多西拉敏过量：言语含糊和视幻觉。《土耳其儿科学杂志》2018年；60：439 - 442。琥珀酸多西拉敏是一种常用的抗组胺药，用于治疗包括过敏性鼻炎在内的呼吸道过敏以及失眠。由于它像其他非处方抗组胺药和助眠药一样可在柜台购买，存在过量使用的风险。据信，琥珀酸多西拉敏因其抗胆碱能特性具有外周和中枢活性。谵妄、癫痫发作和昏迷是罕见的中枢不良反应。本病例被呈现出来是因为这是文献中首例在高剂量使用琥珀酸多西拉敏后出现言语含糊和视幻觉并接受抗胆碱能副作用解毒治疗的病例。
