Department of Physiology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Faculty of Health, School of Exercise and Nutrition Sciences, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
Arch Gynecol Obstet. 2023 Oct;308(4):1075-1084. doi: 10.1007/s00404-023-06925-w. Epub 2023 Jan 31.
Nausea and vomiting during pregnancy (NVP) are common symptoms in pregnancy. Although no definitive treatment option for NVP, pyridoxine (Vitamin B6) supplementation has been used widely. The present study aims to systematically evaluate the current evidence regarding pyridoxine for the treatment of NVP.
Data were obtained using a stepwise search process using keywords in the following online medical databases; PubMed, Web of Science, and Scopus for studies published before 1st May 2021. Studies reporting intervention with pyridoxine supplementation alone and/or with other active substances were included. A meta-analysis was performed on the PUQE score and Rhode's score for nausea and vomiting.
Initial database searching indicated 548 potentially eligible articles, of which 18 studies satisfying the inclusion criteria were selected. Eight studies showed beneficial effects with pyridoxine alone as the supplementation, while six others found that the supplementation of pyridoxine in combination with another active substance had favourable effects. Supplementation of pyridoxine alone as well as combined treatment of pyridoxine with an active ingredient as the intervention significantly improved the symptoms of nausea according to Rhode's score [0.78 [95% CI: 0.26, 1.31; p = 0.003; I2 = 57%, p = 0.10)] and PUQE score [0.75 (95% CI: 0.28, 1.22; p = 0.002; I2 = 0%, p = 0.51)], respectively.
Supplementation of pyridoxine alone as well as with an active ingredient demonstrated beneficial effects for women suffering from NVP.
妊娠恶心和呕吐（NVP）是妊娠的常见症状。尽管没有针对 NVP 的明确治疗选择，但已广泛使用吡哆醇（维生素 B6）补充剂。本研究旨在系统评估吡哆醇治疗 NVP 的现有证据。
使用以下在线医学数据库中的关键词逐步搜索过程获得数据; PubMed、Web of Science 和 Scopus，用于检索 2021 年 5 月 1 日之前发表的研究。报告单独使用吡哆醇补充剂和/或与其他活性物质进行干预的研究均包括在内。对 PUQE 评分和 Rhode 评分的恶心和呕吐进行了荟萃分析。
初步数据库搜索表明有 548 篇潜在合格文章，其中有 18 项符合纳入标准的研究被选中。八项研究表明单独使用吡哆醇具有有益效果，而其他六项研究发现吡哆醇与另一种活性物质联合补充具有有利效果。单独补充吡哆醇以及联合治疗吡哆醇与活性成分作为干预措施均显著改善了根据 Rhode 评分[0.78 [95% CI：0.26, 1.31; p=0.003; I2=57%, p=0.10)]和 PUQE 评分[0.75（95% CI：0.28, 1.22; p=0.002; I2=0%, p=0.51)]评估的恶心症状。
单独补充吡哆醇以及与活性成分联合补充对患有 NVP 的女性均有有益效果。
