用于溶解胆红素钙结石的乙二胺四乙酸溶液。

EDTA solutions for the dissolution of calcium bilirubinate stones.

作者信息

Leuschner U, Baumgärtel H, Leuschner M, Frenk H, Klicic X

出版信息

Digestion. 1986;34(1):36-45. doi: 10.1159/000199308.

DOI:10.1159/000199308

Abstract

The calcium chelating of different EDTA solutions was investigated after addition of 5.49% calcium bilirubinate powder. Calcium chelating seems to be an essential step in disaggregation of pigment stones. We found that Ca chelating is pH dependent and that the system must be buffered in order to prevent pH shifting during the dissolution process. When an alkaline (pH 9.4), buffered 1% EDTA solution is mixed with bile in a ratio of 70:30, dissolution of Ca will decrease to 60% as compared to investigations without bile. Furthermore, we could demonstrate that the EDTA solution would not only dissolve Ca bilirubinate powder, but complete bovine pigment stones of homogeneous structure and mostly inhomogenously composed stones of man as well.

摘要

在添加5.49%的胆红素钙粉末后，对不同乙二胺四乙酸（EDTA）溶液的钙螯合作用进行了研究。钙螯合似乎是色素结石分解的一个关键步骤。我们发现钙螯合作用取决于pH值，并且为了防止溶解过程中pH值发生变化，该体系必须进行缓冲。当碱性（pH 9.4）的、经过缓冲的1% EDTA溶液与胆汁按70:30的比例混合时，与不添加胆汁的研究相比，钙的溶解率将降至60%。此外，我们还证明了EDTA溶液不仅能溶解胆红素钙粉末，还能溶解结构均匀的完整牛色素结石以及大多数人身上结构不均一的结石。