HOMA-IR 与美国中老年人群虚弱的相关性研究。
Association between HOMA-IR and Frailty among U.S. Middle-aged and Elderly Population.
机构信息
Division of Cardiology, Department of Internal Medicine, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, Republic of China.
Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
出版信息
Sci Rep. 2019 Mar 12;9(1):4238. doi: 10.1038/s41598-019-40902-1.
Previous literatures revealed that homeostasis model assessment-estimated insulin resistance (HOMA-IR) was one of the cardio-metabolic risk factors. This study was conducted to access the association between HOMA-IR and frailty in the United States of America (U.S.) middle-aged and elderly high-risk insulin-resistant population. In the National Health and Nutrition Examination Survey (NHANES III) from 1988 to 1994, the study included 3,893 participants. In order to exam the association between HOMA-IR and frailty in the middle-aged and elderly population through the regression model adjusted for multiple covariates, we divided the participants into middle aged group (Age <65 years) and elderly group (Age > = 65 years) in this study. Each group was then divided into tertiles depending on their HOMA-IR levels. Higher level of HOMA-IR was significantly associated with frailty in the elderly group, but this association was not seen in the middle-aged population. These results demonstrated that the HOMA-IR level can be a novel risk assessment of frailty in elderly high-risk insulin-resistant individuals (Age > = 65 years).
先前的文献表明，稳态模型评估-估计的胰岛素抵抗（HOMA-IR）是心血管代谢危险因素之一。本研究旨在评估美国中年和老年高危胰岛素抵抗人群中 HOMA-IR 与虚弱之间的关系。在 1988 年至 1994 年的全国健康和营养检查调查（NHANES III）中，研究纳入了 3893 名参与者。为了通过调整多个协变量的回归模型来研究 HOMA-IR 与中年和老年人虚弱之间的关系，我们将参与者分为中年组（年龄 <65 岁）和老年组（年龄 >=65 岁）。然后，根据 HOMA-IR 水平将每组进一步分为三分位组。在老年组中，较高的 HOMA-IR 水平与虚弱显著相关，但在中年人群中未观察到这种关联。这些结果表明，HOMA-IR 水平可以作为老年高危胰岛素抵抗个体（年龄>=65 岁）虚弱的新的风险评估指标。
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