Division of Cardiology, Department of Internal Medicine, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, Republic of China.
Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Sci Rep. 2019 Mar 12;9(1):4238. doi: 10.1038/s41598-019-40902-1.
Previous literatures revealed that homeostasis model assessment-estimated insulin resistance (HOMA-IR) was one of the cardio-metabolic risk factors. This study was conducted to access the association between HOMA-IR and frailty in the United States of America (U.S.) middle-aged and elderly high-risk insulin-resistant population. In the National Health and Nutrition Examination Survey (NHANES III) from 1988 to 1994, the study included 3,893 participants. In order to exam the association between HOMA-IR and frailty in the middle-aged and elderly population through the regression model adjusted for multiple covariates, we divided the participants into middle aged group (Age <65 years) and elderly group (Age > = 65 years) in this study. Each group was then divided into tertiles depending on their HOMA-IR levels. Higher level of HOMA-IR was significantly associated with frailty in the elderly group, but this association was not seen in the middle-aged population. These results demonstrated that the HOMA-IR level can be a novel risk assessment of frailty in elderly high-risk insulin-resistant individuals (Age > = 65 years).
先前的文献表明，稳态模型评估-估计的胰岛素抵抗（HOMA-IR）是心血管代谢危险因素之一。本研究旨在评估美国中年和老年高危胰岛素抵抗人群中 HOMA-IR 与虚弱之间的关系。在 1988 年至 1994 年的全国健康和营养检查调查（NHANES III）中，研究纳入了 3893 名参与者。为了通过调整多个协变量的回归模型来研究 HOMA-IR 与中年和老年人虚弱之间的关系，我们将参与者分为中年组（年龄 <65 岁）和老年组（年龄 >=65 岁）。然后，根据 HOMA-IR 水平将每组进一步分为三分位组。在老年组中，较高的 HOMA-IR 水平与虚弱显著相关，但在中年人群中未观察到这种关联。这些结果表明，HOMA-IR 水平可以作为老年高危胰岛素抵抗个体（年龄>=65 岁）虚弱的新的风险评估指标。
