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热共还原法制备的银纳米颗粒对Wistar大鼠肝脏造成损伤:急性和亚慢性毒性分析

Silver nanoparticles engineered by thermal co-reduction approach induces liver damage in Wistar rats: acute and sub-chronic toxicity analysis.

作者信息

Dasgupta Nandita, Ranjan Shivendu, Ramalingam Chidambaram, Gandhi Mansi

机构信息

1Nano-food Research Group, Instrumental and Food Analysis Laboratory, Industrial Biotechnology Division, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu India.

2Department of Biotechnology, Institute of Engineering and Technology, Dr. APJ Abdul Kalam Technical University (Formerly Uttar Pradesh Technical University), Lucknow, Uttar Pradesh 226021 India.

出版信息

3 Biotech. 2019 Apr;9(4):125. doi: 10.1007/s13205-019-1651-6. Epub 2019 Mar 6.

Abstract

Recently, nanotechnology applications have increased tremendously in consumer products. However, it has been observed that these nanoparticles can cause a potential risk to the environment as well as human health. In the present manuscript, we have analyzed acute and sub-chronic toxicity of engineered silver nanoparticles (AgNPs) by assessing the impact on Wistar rats. AgNPs were synthesized by a novel approach-thermal co-reduction-with spherical shape and a uniform size distribution of 60 nm. The estimated LD value was observed to be more than 2000 mg/kg bw in acute toxicity studies. Sub-chronic toxicity indicated impairment of liver and kidney enzymes and various hematological and biochemical parameters. Tissue distribution studies indicated the target organ for accumulation is liver after treatment with AgNP. Particle deposition and congestion was observed in major organs-though, and heart and pancreatic tissues were not affected even by the higher doses. On the basis of the observations of this study, it is concluded that up to 40 mg/kgbw is a safer dose of AgNPs (60 nm, engineered by thermal co-reduction approach) and further research will be required to validate the long-term accumulation in body. In addition, it can also be considered by policymakers for the safer use of AgNPs.

摘要

近年来,纳米技术在消费品中的应用急剧增加。然而,人们观察到这些纳米颗粒可能对环境以及人类健康造成潜在风险。在本论文中,我们通过评估对Wistar大鼠的影响,分析了工程化银纳米颗粒(AgNPs)的急性和亚慢性毒性。AgNPs采用一种新颖的方法——热共还原法合成,呈球形,尺寸分布均匀,为60纳米。在急性毒性研究中,估计的半数致死量值超过2000毫克/千克体重。亚慢性毒性表明肝脏和肾脏酶以及各种血液学和生化参数受损。组织分布研究表明,用AgNP处理后,积累的靶器官是肝脏。不过,在主要器官中观察到了颗粒沉积和充血现象,即使是高剂量也未影响心脏和胰腺组织。基于本研究的观察结果,得出结论:高达40毫克/千克体重是AgNPs(60纳米,通过热共还原法工程化)的安全剂量,需要进一步研究来验证其在体内的长期积累情况。此外,政策制定者在安全使用AgNPs时也可予以考虑。

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