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HDAC-dependent decrease in histone crotonylation during DNA damage.

作者信息

Abu-Zhayia Enas R, Machour Feras E, Ayoub Nabieh

机构信息

Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel.

出版信息

J Mol Cell Biol. 2019 Sep 19;11(9):804-806. doi: 10.1093/jmcb/mjz019.

DOI:10.1093/jmcb/mjz019
PMID:30864665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6821229/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de41/6821229/e7468bc78bf5/mjz019f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de41/6821229/e7468bc78bf5/mjz019f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de41/6821229/e7468bc78bf5/mjz019f1.jpg

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Protein Dynamics in Complex DNA Lesions.复杂 DNA 损伤中的蛋白质动力学。
Mol Cell. 2018 Mar 15;69(6):1046-1061.e5. doi: 10.1016/j.molcel.2018.02.016.
2
CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair.CDYL1 促进双链断裂诱导的转录沉默，并促进同源定向修复。
J Mol Cell Biol. 2018 Aug 1;10(4):341-357. doi: 10.1093/jmcb/mjx050.
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Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.
组蛋白修饰：糖尿病视网膜病变的潜在治疗靶点
Biomolecules. 2025 Apr 12;15(4):575. doi: 10.3390/biom15040575.
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Conversion of Ku80 K568 crotonylation to SUMOylation facilitates DNA non-homologous end joining and cancer radioresistance.Ku80的K568巴豆酰化向SUMO化的转变促进DNA非同源末端连接和癌症放射抗性。
Signal Transduct Target Ther. 2025 Apr 21;10(1):127. doi: 10.1038/s41392-025-02210-1.
5
Identification and validation of crotonylation-related diagnostic markers for lung adenocarcinoma via weighted correlation network analysis and machine learning.通过加权相关网络分析和机器学习鉴定及验证肺腺癌中与巴豆酰化相关的诊断标志物
Transl Lung Cancer Res. 2025 Mar 31;14(3):940-962. doi: 10.21037/tlcr-2025-204. Epub 2025 Mar 27.
6
Histone Lysine Crotonylation Regulates Long-Term Memory Storage.组蛋白赖氨酸巴豆酰化调控长期记忆存储。
bioRxiv. 2025 Feb 19:2025.02.19.639114. doi: 10.1101/2025.02.19.639114.
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Regulatory Mechanism of Protein Crotonylation and Its Relationship with Cancer.蛋白巴豆酰化的调控机制及其与癌症的关系。
Cells. 2024 Nov 2;13(21):1812. doi: 10.3390/cells13211812.
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Crotonylation of MCM6 enhances chemotherapeutics sensitivity of breast cancer via inducing DNA replication stress.MCM6的巴豆酰化通过诱导DNA复制应激增强乳腺癌的化疗敏感性。
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