V1 层在视觉空间感知过程中的皮层状态波动。

Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.

University College London, Gower Street, London WC1E 6BT, UK.

Cell Rep. 2019 Mar 12;26(11):2868-2874.e3. doi: 10.1016/j.celrep.2019.02.045.

Many factors modulate the state of cortical activity, but the importance of cortical state variability for sensory perception remains debated. We trained mice to detect spatially localized visual stimuli and simultaneously measured local field potentials and excitatory and inhibitory neuron populations across layers of primary visual cortex (V1). Cortical states with low spontaneous firing and correlations in excitatory neurons, and suppression of 3- to 7-Hz oscillations in layer 4, accurately predicted single-trial visual detection. Our results show that cortical states exert strong effects at the initial stage of cortical processing in V1 and can play a prominent role for visual spatial behavior in mice.

许多因素调节皮层活动状态，但皮层状态可变性对感觉感知的重要性仍存在争议。我们训练小鼠检测空间定位的视觉刺激，同时在初级视觉皮层（V1）的各层测量局部场电位和兴奋性及抑制性神经元群体。具有低自发放电和兴奋性神经元相关性，以及抑制 3-7Hz 振荡的皮层状态，可准确预测单试次视觉检测。我们的结果表明，皮层状态在 V1 的皮层处理初始阶段产生强烈影响，并且在小鼠的视觉空间行为中发挥重要作用。