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Disrupting redox stabilizer: a novel therapeutic strategy for colorectal cancer.

作者信息

Trachootham Dunyaporn, Khoonin Watcharapol

机构信息

Institute of Nutrition, Mahidol University, 999 Phutthamonthon Sai 4 Road, Salaya, Nakhon Pathom, 73170, Thailand.

Chulabhorn Oncology Medical Center, Chulabhorn Hospital, Bangkok, 10210, Thailand.

出版信息

Cancer Commun (Lond). 2019 Mar 12;39(1):9. doi: 10.1186/s40880-019-0355-y.

DOI:10.1186/s40880-019-0355-y
PMID:30867065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6416897/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6332/6416897/e65fb453c1f8/40880_2019_355_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6332/6416897/921eb7dccf4e/40880_2019_355_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6332/6416897/e65fb453c1f8/40880_2019_355_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6332/6416897/921eb7dccf4e/40880_2019_355_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6332/6416897/e65fb453c1f8/40880_2019_355_Fig2_HTML.jpg

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Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications.抑制 MTHFD2 对结直肠癌氧化还原平衡的调节：机制与治疗意义。
J Natl Cancer Inst. 2019 Jun 1;111(6):584-596. doi: 10.1093/jnci/djy160.
2
Metabolic recoding of epigenetics in cancer.癌症中表观遗传学的代谢重编程。
Cancer Commun (Lond). 2018 May 21;38(1):25. doi: 10.1186/s40880-018-0302-3.
3
Disrupting G6PD-mediated Redox homeostasis enhances chemosensitivity in colorectal cancer.破坏葡萄糖-6-磷酸脱氢酶（G6PD）介导的氧化还原稳态可增强结直肠癌的化疗敏感性。
Oncogene. 2017 Nov 9;36(45):6282-6292. doi: 10.1038/onc.2017.227. Epub 2017 Jul 10.
4
Revisiting the hallmarks of cancer.重探癌症的特征
Am J Cancer Res. 2017 May 1;7(5):1016-1036. eCollection 2017.
5
One-Carbon Metabolism in Health and Disease.健康与疾病中的一碳代谢
Cell Metab. 2017 Jan 10;25(1):27-42. doi: 10.1016/j.cmet.2016.08.009. Epub 2016 Sep 15.
6
Oxidative stress inhibits distant metastasis by human melanoma cells.氧化应激抑制人黑色素瘤细胞的远处转移。
Nature. 2015 Nov 12;527(7577):186-91. doi: 10.1038/nature15726. Epub 2015 Oct 14.
7
Quantitative flux analysis reveals folate-dependent NADPH production.定量通量分析揭示了叶酸依赖性 NADPH 的产生。
Nature. 2014 Jun 12;510(7504):298-302. doi: 10.1038/nature13236. Epub 2014 May 4.
8
Folic acid supplementation promotes mammary tumor progression in a rat model.叶酸补充剂促进大鼠模型中的乳腺肿瘤进展。
PLoS One. 2014 Jan 21;9(1):e84635. doi: 10.1371/journal.pone.0084635. eCollection 2014.
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