Ziaee Amir, Ghorbani Azam, Kalbasi Saied, Hejrati Alireza, Moradi Saba
M.D., Endocrinologist, Professor, Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
M.Sc., MSN, of Nursing Education, Faculty Member, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Electron Physician. 2017 Sep 25;9(9):5206-5211. doi: 10.19082/5206. eCollection 2017 Sep.
Prediabetes is a condition that occurs when blood glucose levels are higher than normal, but not high enough to be classified as diabetes. Prediabetic people have an increased risk of developing type 2 diabetes and cardiovascular disease. Moreover Hyperglycemia has multiple effects on the hematological parameters.
To examine the association between hematological indices and anthropometric measurement, with prediabetes.
This cross-sectional study was conducted on 125 diabetics and 259 prediabetics in the 20-70 age range. They were selected by a convenience sampling method at the Taban Diabetes Center in 2015. An oral glucose tolerance test was performed for each participant who had never been diagnosed with diabetes. Participants were characterized as having prediabetes or diabetes according to American Diabetes Association criteria. The hematologic parameters were measured by using Sysmex-KX 21N analyzers. Data were analyzed by IBM-SPSS version 22 using independent-samples t-test, Mann-Whitney U test, and Pearson's correlation coefficient at p<0.05.
There was significant difference in mean corpuscular hemoglobin concentration (MCVH) (33.81±0.92 g/dL vs. 34.06±1.05 g/dL) between prediabetes patients and diabetes. There was not a statistically significant difference in the prediabetics' hematological parameters, compared with the diabetics. In the prediabetic group, only the mean corpuscular hemoglobin concentration was found to be negatively correlated with diastolic blood pressure (p=0.013) and FBS (p=0.026).
Hematological indices are important markers for the assessment of variations in size, number, and maturity of different blood cells. Hematological indices could be utile indicators of vascular complication and glycemic control in type 2 DM patients. Thus, they are important for the evaluation and early management of patients with per diabetes.
糖尿病前期是指血糖水平高于正常，但又未高到可被归类为糖尿病的一种状态。糖尿病前期患者患2型糖尿病和心血管疾病的风险增加。此外，高血糖对血液学参数有多种影响。
研究血液学指标与人体测量指标和糖尿病前期之间的关联。
本横断面研究选取了20至70岁的125名糖尿病患者和259名糖尿病前期患者。2015年在塔班糖尿病中心采用便利抽样法选取研究对象。对每位从未被诊断为糖尿病的参与者进行口服葡萄糖耐量试验。根据美国糖尿病协会标准将参与者分为糖尿病前期或糖尿病患者。使用Sysmex-KX 21N分析仪测量血液学参数。采用IBM-SPSS 22版软件进行数据分析，使用独立样本t检验、曼-惠特尼U检验和Pearson相关系数，p<0.05。
糖尿病前期患者与糖尿病患者之间的平均红细胞血红蛋白浓度（MCVH）存在显著差异（33.81±0.92 g/dL对34.06±1.05 g/dL）。与糖尿病患者相比，糖尿病前期患者的血液学参数无统计学显著差异。在糖尿病前期组中，仅发现平均红细胞血红蛋白浓度与舒张压（p=0.013）和空腹血糖（p=0.026）呈负相关。
血液学指标是评估不同血细胞大小、数量和成熟度变化的重要标志物。血液学指标可能是2型糖尿病患者血管并发症和血糖控制的有用指标。因此，它们对糖尿病前期患者的评估和早期管理很重要。
