埃塞俄比亚东部2型糖尿病成年患者的红细胞参数及其与血糖控制的相关性：一项比较性横断面研究
Red Blood Cell Parameters and Their Correlation with Glycemic Control Among Type 2 Diabetic Adult Patients in Eastern Ethiopia: A Comparative Cross-Sectional Study.
作者信息
Arkew Mesay, Asmerom Haftu, Tesfa Tewodros, Tsegaye Setegn, Gemechu Kabtamu, Bete Tilahun, Haile Kassahun
机构信息
School of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
College of Health and Medical Sciences, Debre Berhan University, Debre Berhan, Ethiopia.
出版信息
Diabetes Metab Syndr Obes. 2022 Nov 9;15:3499-3507. doi: 10.2147/DMSO.S386093. eCollection 2022.
BACKGROUND
Diabetes has been proposed to inflict an insult on the hematopoietic milieu marked by changes in hematological indices including red blood cell parameters. Thus, this study aimed to assess the red blood cell parameters and their correlation with glycemic control in type 2 diabetic adult patients in comparison with apparently healthy individuals.
METHODS
A comparative cross-sectional study was conducted at the chronic illness clinic of Hiwot Fana Comprehensive Specialized University Hospital from May 20 to July 10, 2022. A total of 220 (110 type 2 diabetic patients and 110 controls) study participants were selected by a simple random sampling technique. Five milliliters of venous blood were collected by the vacutainer blood collection technique. Red blood cell parameters and blood glucose levels were determined using UniCel DxH 800 and Biosystems A25 analyzers, respectively. Independent sample -test and Pearson correlation test were used for the data analysis. P-value <0.05 was considered statistically significant.
RESULTS
Statistically significant difference was observed in RBC parameters of T2DM patients and the control group. The mean RBC count, Hgb, Hct (P < 0.001), and MCHC (P = 0.002) in patients with type 2 diabetes was significantly lower than in the control group. However, the mean of RDW was significantly increased in type 2 diabetic patient groups than in the control group (P < 0.001). The mean RBC count, Hct, and Hgb in patients with good glycemic control were significantly higher than the patients with poor glycemic control. Besides, a statistically significant negative correlation was observed between glycemic control and RBC count, Hgb, and Hct level in diabetic patients.
CONCLUSION
In this study, a statistically significant difference was observed in red blood cell parameters of type 2 diabetic patients compared to the control group. A significant negative correlation was noted between glycemic control and RBC parameters in type 2 diabetic patients. Therefore, evaluation of RBC parameters should be considered for better management of patients with type 2 diabetes mellitus.
背景
糖尿病被认为会对造血环境造成损害，其特征是血液学指标发生变化，包括红细胞参数。因此，本研究旨在评估2型糖尿病成年患者的红细胞参数及其与血糖控制的相关性，并与明显健康的个体进行比较。
方法
2022年5月20日至7月10日，在Hiwot Fana综合专科医院慢性病门诊进行了一项比较横断面研究。通过简单随机抽样技术共选取了220名研究参与者（110名2型糖尿病患者和110名对照）。采用真空采血管采血技术采集5毫升静脉血。分别使用UniCel DxH 800和Biosystems A25分析仪测定红细胞参数和血糖水平。数据分析采用独立样本t检验和Pearson相关检验。P值<0.05被认为具有统计学意义。
结果
2型糖尿病患者和对照组的红细胞参数存在统计学显著差异。2型糖尿病患者的平均红细胞计数、血红蛋白、血细胞比容（P<0.001）和平均红细胞血红蛋白浓度（P = 0.002）显著低于对照组。然而，2型糖尿病患者组的平均红细胞分布宽度显著高于对照组（P<0.001）。血糖控制良好的患者的平均红细胞计数、血细胞比容和血红蛋白显著高于血糖控制不佳的患者。此外，糖尿病患者的血糖控制与红细胞计数、血红蛋白和血细胞比容水平之间存在统计学显著的负相关。
结论
在本研究中，2型糖尿病患者的红细胞参数与对照组相比存在统计学显著差异。2型糖尿病患者的血糖控制与红细胞参数之间存在显著负相关。因此，为了更好地管理2型糖尿病患者，应考虑评估红细胞参数。
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