• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一个六 miRNA -signature 预测胃癌患者的预后。

A six-microRNA signature to predict outcomes of patients with gastric cancer.

机构信息

Department of Oncology The First Affiliated Hospital of University of Science and Technology of China Hefei China.

出版信息

FEBS Open Bio. 2019 Jan 31;9(3):538-547. doi: 10.1002/2211-5463.12593. eCollection 2019 Mar.

DOI:10.1002/2211-5463.12593
PMID:30868062
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6396146/
Abstract

Gastric cancer (GC) is a common gastrointestinal tumor with poor prognosis. However, conventional prognostic factors cannot accurately predict the outcomes of GC patients. Therefore, there remains a need to identify novel predictive markers to improve prognosis. In this study, we obtained microRNA expression profiles of 385 GC patients from The Cancer Genome Atlas. We performed Cox regression analysis to identify overall survival-related microRNA and then constructed a microRNA signature-based prognostic model. The accuracy of the model was evaluated and validated through Kaplan-Meier survival analysis and time-dependent receiver operating characteristic (ROC) curve analysis. The independent prognostic value of the model was assessed by multivariate Cox regression analysis. Enrichment analysis was performed to explore potential functions of the prognostic microRNA. Finally, a prognostic model based on a six-microRNA (miRNA-100, miRNA-374a, miRNA-509-3, miRNA-668, miRNA-549, and miRNA-653) signature was developed. Further analysis in the training, test, and complete The Cancer Genome Atlas set showed the model can distinguish between high-risk and low-risk patients and predict 3-year and 5-year survival. The six-microRNA signature was also an independent prognostic marker, and enrichment analysis suggested that the microRNA may be involved in cell cycle and mitosis. These results demonstrated that the model based on the six-microRNA signature can be used to accurately predict the prognosis of GC patients.

摘要

胃癌（GC）是一种常见的胃肠道肿瘤，预后较差。然而，传统的预后因素不能准确预测 GC 患者的结局。因此，仍然需要识别新的预测标志物来改善预后。在这项研究中，我们从癌症基因组图谱中获得了 385 例 GC 患者的 microRNA 表达谱。我们进行了 Cox 回归分析，以确定与总生存期相关的 microRNA，然后构建了基于 microRNA 特征的预后模型。通过 Kaplan-Meier 生存分析和时间依赖性 ROC 曲线分析评估和验证了模型的准确性。通过多变量 Cox 回归分析评估了模型的独立预后价值。进行了富集分析以探讨预后 microRNA 的潜在功能。最后，开发了基于六个 microRNA（miRNA-100、miRNA-374a、miRNA-509-3、miRNA-668、miRNA-549 和 miRNA-653）特征的预后模型。在训练、测试和完整的癌症基因组图谱集中的进一步分析表明，该模型可以区分高风险和低风险患者，并预测 3 年和 5 年的生存率。这六个 microRNA 特征也是一个独立的预后标志物，富集分析表明 microRNA 可能参与细胞周期和有丝分裂。这些结果表明，基于六个 microRNA 特征的模型可用于准确预测 GC 患者的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec0/6396146/cab8a8db2cb7/FEB4-9-538-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec0/6396146/642aa1d56d4a/FEB4-9-538-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec0/6396146/49bfbbb2f9b1/FEB4-9-538-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec0/6396146/c03c88cca7f4/FEB4-9-538-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec0/6396146/0e65dacc2a14/FEB4-9-538-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec0/6396146/cab8a8db2cb7/FEB4-9-538-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec0/6396146/642aa1d56d4a/FEB4-9-538-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec0/6396146/49bfbbb2f9b1/FEB4-9-538-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec0/6396146/c03c88cca7f4/FEB4-9-538-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec0/6396146/0e65dacc2a14/FEB4-9-538-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec0/6396146/cab8a8db2cb7/FEB4-9-538-g005.jpg

相似文献

1
A six-microRNA signature to predict outcomes of patients with gastric cancer.一个六 miRNA -signature 预测胃癌患者的预后。
FEBS Open Bio. 2019 Jan 31;9(3):538-547. doi: 10.1002/2211-5463.12593. eCollection 2019 Mar.
2
Genome-wide identification of a novel miRNA-based signature to predict recurrence in patients with gastric cancer.基于全基因组鉴定的新型 miRNA 标志物预测胃癌患者的复发。
Mol Oncol. 2018 Dec;12(12):2072-2084. doi: 10.1002/1878-0261.12385. Epub 2018 Oct 10.
3
Three-microRNA signature identified by bioinformatics analysis predicts prognosis of gastric cancer patients.基于生物信息学分析鉴定的三 miRNA -signature 预测胃癌患者的预后。
World J Gastroenterol. 2018 Mar 21;24(11):1206-1215. doi: 10.3748/wjg.v24.i11.1206.
4
A novel microRNA signature predicts survival in stomach adenocarcinoma.一种新型微小RNA特征可预测胃腺癌的生存率。
Oncotarget. 2017 Apr 25;8(17):28144-28153. doi: 10.18632/oncotarget.15961.
5
Plasma microRNA-based signatures to predict 3-year postoperative recurrence risk for stage II and III gastric cancer.基于血浆 microRNA 的特征预测 II 期和 III 期胃癌的 3 年术后复发风险。
Int J Cancer. 2017 Nov 15;141(10):2093-2102. doi: 10.1002/ijc.30895. Epub 2017 Jul 28.
6
Analysis of microRNA expression profiles reveals a 5‑microRNA prognostic signature for predicting overall survival time in patients with gastric adenocarcinoma.分析 microRNA 表达谱揭示了 5 个 microRNA 预后标志物，可预测胃腺癌患者的总生存时间。
Oncol Rep. 2019 May;41(5):2775-2789. doi: 10.3892/or.2019.7048. Epub 2019 Mar 7.
7
A four-miRNA signature as a novel biomarker for predicting survival in endometrial cancer.一个四 miRNA 特征作为预测子宫内膜癌患者生存的新型生物标志物。
Gene. 2019 May 20;697:86-93. doi: 10.1016/j.gene.2019.01.046. Epub 2019 Feb 16.
8
MicroRNA hsa-mir-3923 serves as a diagnostic and prognostic biomarker for gastric carcinoma.微小 RNA hsa-mir-3923 可作为胃癌的诊断和预后生物标志物。
Sci Rep. 2020 Mar 13;10(1):4672. doi: 10.1038/s41598-020-61633-8.
9
The prognostic value of a seven-microRNA classifier as a novel biomarker for the prediction and detection of recurrence in glioma patients.一种七微RNA分类器作为预测和检测胶质瘤患者复发的新型生物标志物的预后价值。
Oncotarget. 2016 Aug 16;7(33):53392-53413. doi: 10.18632/oncotarget.10534.
10
A six-microRNA risk score model predicts prognosis in esophageal squamous cell carcinoma.一个六 miRNA 风险评分模型预测食管鳞癌的预后。
J Cell Physiol. 2019 May;234(5):6810-6819. doi: 10.1002/jcp.27429. Epub 2018 Nov 1.

引用本文的文献

1
The Value of Serum miR-139-3p Expression Level in Predicting Postoperative Survival of Colon Cancer Patients.血清miR-139-3p表达水平在预测结肠癌患者术后生存中的价值
Int J Gen Med. 2022 Feb 11;15:1405-1412. doi: 10.2147/IJGM.S346674. eCollection 2022.
2
Knockdown of CENPK inhibits cell growth and facilitates apoptosis via PTEN-PI3K-AKT signalling pathway in gastric cancer.敲低 CENPK 通过 PTEN-PI3K-AKT 信号通路抑制胃癌细胞生长并促进细胞凋亡。
J Cell Mol Med. 2021 Sep;25(18):8890-8903. doi: 10.1111/jcmm.16850. Epub 2021 Aug 12.
3
Systematic Review of Prognostic Gene Signature in Gastric Cancer Patients.

本文引用的文献

1
The prognosis role of AJCC/UICC 8 edition staging system in gastric cancer, a retrospective analysis.AJCC/UICC第8版分期系统在胃癌中的预后作用：一项回顾性分析
Am J Transl Res. 2018 Jan 15;10(1):292-303. eCollection 2018.
2
Analysis of expression profile of miRNA in stomach adenocarcinoma.胃腺癌中miRNA表达谱分析
J BUON. 2017 Sep-Oct;22(5):1154-1159.
3
Comprehensive analysis of a novel four-lncRNA signature as a prognostic biomarker for human gastric cancer.一种新型四lncRNA特征作为人类胃癌预后生物标志物的综合分析
胃癌患者预后基因特征的系统评价
Front Bioeng Biotechnol. 2020 Jul 31;8:805. doi: 10.3389/fbioe.2020.00805. eCollection 2020.
4
Limb-bud and heart as a novel biomarker for gastric intestinal type adenocarcinoma.肢芽和心脏作为胃肠型腺癌的一种新型生物标志物。
Oncol Lett. 2020 Sep;20(3):2209-2216. doi: 10.3892/ol.2020.11778. Epub 2020 Jun 25.
Oncotarget. 2017 Aug 24;8(43):75007-75024. doi: 10.18632/oncotarget.20496. eCollection 2017 Sep 26.
4
Identification and validation of a prognostic 9-genes expression signature for gastric cancer.胃癌预后9基因表达特征的鉴定与验证
Oncotarget. 2017 May 10;8(43):73826-73836. doi: 10.18632/oncotarget.17764. eCollection 2017 Sep 26.
5
miR-509-3-5P inhibits the invasion and lymphatic metastasis by targeting PODXL and serves as a novel prognostic indicator for gastric cancer.微小RNA-509-3-5P通过靶向Podocalyxin样蛋白抑制侵袭和淋巴转移，并作为胃癌的一种新型预后指标。
Oncotarget. 2017 May 23;8(21):34867-34883. doi: 10.18632/oncotarget.16802.
6
miR-668 enhances the radioresistance of human breast cancer cell by targeting IκBα.微小RNA-668通过靶向IκBα增强人乳腺癌细胞的辐射抗性。
Breast Cancer. 2017 Sep;24(5):673-682. doi: 10.1007/s12282-017-0756-1. Epub 2017 Jan 30.
7
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study.全球、区域和国家癌症发病率、死亡率、生命损失年数、失能生存年数以及 32 种癌症组别的伤残调整生命年数，1990 年至 2015 年：全球疾病负担研究的系统分析。
JAMA Oncol. 2017 Apr 1;3(4):524-548. doi: 10.1001/jamaoncol.2016.5688.
8
MiR-509-3-5p causes aberrant mitosis and anti-proliferative effect by suppression of PLK1 in human lung cancer A549 cells.MiR-509-3-5p通过抑制人肺癌A549细胞中的PLK1导致异常有丝分裂和抗增殖作用。
Biochem Biophys Res Commun. 2016 Sep 16;478(2):676-82. doi: 10.1016/j.bbrc.2016.08.006. Epub 2016 Aug 3.
9
Expression and clinical significance of miRNAs that may be associated with the FHIT gene in breast cancer.可能与乳腺癌中FHIT基因相关的微小RNA的表达及临床意义
Gene. 2016 Sep 30;590(2):278-84. doi: 10.1016/j.gene.2016.05.033. Epub 2016 May 25.
10
microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway.微小RNA-374a通过直接降低细胞周期蛋白D1使PI3K/AKT信号通路失活，从而抑制结肠癌进展。
Oncotarget. 2016 Jul 5;7(27):41306-41319. doi: 10.18632/oncotarget.9320.