Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, 21, Avenida Catalunya, 46020 Valencia, Spain; Analytical Chemistry Department, University of Valencia, Edifici Jeroni Muñoz, Dr. Moliner 50, 46100 Burjassot, Spain; Public Health Laboratory of Valencia, 21, Avenida Catalunya, 46020 Valencia, Spain.
Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, 21, Avenida Catalunya, 46020 Valencia, Spain.
Sci Total Environ. 2019 Jun 10;668:797-805. doi: 10.1016/j.scitotenv.2019.03.024. Epub 2019 Mar 3.
The present study addresses the presence of bisphenols A (BPA) and its analogs bisphenol F (BPF) and S (BPS) in milk of 120 mothers living in Valencia (Spain) and participating in the BETTERMILK project (year 2015). We also studied the factors that could influence the BPA levels and estimated the exposure and the risk for breast fed infants. The frequency of detection of total (conjugated + unconjugated) and unconjugated-BPA were 83% and 77%, with a geometric mean of 0.29 ng/mL and 0.15 ng/mL, respectively. The frequency of detection was much lower for total-BPF (22%) and total-BPS (1.1%). The place of residence of the mother and the use of personal care products showed significant association with BPA concentrations. The estimated daily intake of total-BPA for breastfed infants amounted to a geometric mean of 0.04 μg/kg bw and a 95th percentile of 1.0 μg/kg bw, below the tolerable daily intake of 4 μg/kg bw-day established by EFSA. To our knowledge, this is the largest biomonitoring study of bisphenols in human milk in Europe.
本研究调查了居住在西班牙巴伦西亚的 120 名母亲的母乳中是否存在双酚 A（BPA）及其类似物双酚 F（BPF）和 S（BPS），这些母亲参与了 BETTERMILK 项目（2015 年）。我们还研究了可能影响 BPA 水平的因素，并估计了母乳喂养婴儿的暴露和风险。总（结合型+非结合型）和非结合型 BPA 的检出频率分别为 83%和 77%，几何平均值分别为 0.29ng/mL 和 0.15ng/mL。总 BPF（22%）和总 BPS（1.1%）的检出频率要低得多。母亲的居住地和个人护理产品的使用与 BPA 浓度呈显著相关。估计母乳喂养婴儿的总 BPA 日摄入量为 0.04μg/kg bw 的几何平均值和 1.0μg/kg bw 的 95 百分位值，低于 EFSA 规定的 4μg/kg bw-day 可耐受日摄入量。据我们所知，这是欧洲最大的双酚类物质在人乳中的生物监测研究。
