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用于定制聚L-乳酸生物相容性和抗菌表面的环保方法

Eco-Friendly Method for Tailoring Biocompatible and Antimicrobial Surfaces of Poly-L-Lactic Acid.

作者信息

Aflori Magdalena, Butnaru Maria, Tihauan Bianca-Maria, Doroftei Florica

机构信息

Petru Poni Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, Iasi 700487, Romania.

Sanimed International IMPEX SRL, Sos. Bucuresti-Magurele, nr. 70F, Sector 5, Bucharest 051434, Romania.

出版信息

Nanomaterials (Basel). 2019 Mar 13;9(3):428. doi: 10.3390/nano9030428.

DOI:10.3390/nano9030428
PMID:30871241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6474018/
Abstract

In this study, a facile, eco-friendly route, in two steps, for obtaining of poly-L-lactic acid/chitosan-silver nanoparticles scaffolds under quiescent conditions was presented. The method consists of plasma treatment and then wet chemical treatment of poly-L-lactic acid (PLLA) films in a chitosan based-silver nanoparticles solution (Cs/AgNp). The changes of the physical and chemical surface proprieties were studied using scanning electron microscopy (SEM), small angle X-Ray scattering (SAXS), Fourier transform infrared spectroscopy (FTIR) and profilometry methods. A certain combination of plasma treatment and chitosan-based silver nanoparticles solution increased the biocompatibility of PLLA films in combination with cell line seeding as well as the antimicrobial activity for gram-positive and gram-negative bacteria. The sample that demonstrated from Energy Dispersive Spectroscopy (EDAX) to have the highest amount of nitrogen and the smallest amount of Ag, proved to have the highest value for cell viability, demonstrating better biocompatibility and very good antimicrobial proprieties.

摘要

在本研究中，提出了一种简便、环保的两步法，用于在静态条件下制备聚-L-乳酸/壳聚糖-银纳米颗粒支架。该方法包括对聚-L-乳酸（PLLA）薄膜进行等离子体处理，然后在基于壳聚糖的银纳米颗粒溶液（Cs/AgNp）中进行湿化学处理。使用扫描电子显微镜（SEM）、小角X射线散射（SAXS）、傅里叶变换红外光谱（FTIR）和轮廓测量法研究了物理和化学表面性质的变化。等离子体处理和基于壳聚糖的银纳米颗粒溶液的特定组合提高了PLLA薄膜与细胞系接种相结合的生物相容性以及对革兰氏阳性和革兰氏阴性细菌的抗菌活性。通过能量色散光谱（EDAX）证明含氮量最高且银含量最低的样品，其细胞活力值最高，显示出更好的生物相容性和非常好抗菌性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/0921e6acff3e/nanomaterials-09-00428-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/25386e3154be/nanomaterials-09-00428-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/2356f965e4b4/nanomaterials-09-00428-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/62ad14fc59a7/nanomaterials-09-00428-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/d6c2148bd3d8/nanomaterials-09-00428-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/c6c5df4e5366/nanomaterials-09-00428-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/f9430ca481e2/nanomaterials-09-00428-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/c31831040c78/nanomaterials-09-00428-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/fef474cf3369/nanomaterials-09-00428-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/79a88fd6c56e/nanomaterials-09-00428-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/0921e6acff3e/nanomaterials-09-00428-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/25386e3154be/nanomaterials-09-00428-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/2356f965e4b4/nanomaterials-09-00428-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/62ad14fc59a7/nanomaterials-09-00428-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/d6c2148bd3d8/nanomaterials-09-00428-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/c6c5df4e5366/nanomaterials-09-00428-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/f9430ca481e2/nanomaterials-09-00428-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/c31831040c78/nanomaterials-09-00428-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/fef474cf3369/nanomaterials-09-00428-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/79a88fd6c56e/nanomaterials-09-00428-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f1c/6474018/0921e6acff3e/nanomaterials-09-00428-g010.jpg

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