Centre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, Department of Respiratory Medicine, King's College Hospital, London, United Kingdom.
Respiratory Medicine and Pulmonary Rehabilitation Section, Clinic Center, Private Hospital, Naples, Italy.
Pulm Pharmacol Ther. 2019 Jun;56:79-85. doi: 10.1016/j.pupt.2019.03.003. Epub 2019 Mar 11.
Cough is a protective reflex that serves to clear the airways of excessive secretions and foreign matter and which sometimes becomes excessive, and troublesome to patients. Cough is one of the most common reasons why individuals seek medical attention. A range of drugs have been developed in the past with antitussive activity and different mechanisms of action, but there are still very few safe and effective treatments available. The poor tolerability of most available antitussives is closely related to their action on the central nervous system (CNS). An international group of experts specialized in cough met to discuss the need to identify an effective antitussive treatment with a good tolerability profile. The aim of this expert review is to increase the knowledge about the cough mechanism and the activity of levodropropizine, a peripherally acting antitussive drug.
咳嗽是一种保护反射，有助于清除气道中的过多分泌物和异物，但有时会变得过度，给患者带来困扰。咳嗽是人们寻求医疗关注的最常见原因之一。过去已经开发出一系列具有镇咳作用和不同作用机制的药物，但仍然缺乏安全有效的治疗方法。大多数可用镇咳药的耐受性差与其对中枢神经系统（CNS）的作用密切相关。一个专门研究咳嗽的国际专家组开会讨论了确定一种具有良好耐受性的有效镇咳治疗方法的必要性。本次专家综述的目的是增加对咳嗽机制和外周作用镇咳药左羟丙哌嗪活性的了解。
