Dahlbäck M, Bergstrand H, Brattsand R
Allergy. 1986 Apr;41(3):210-9. doi: 10.1111/j.1398-9995.1986.tb00302.x.
We examined the effects of glucocorticosteroids (GCS) on antigen-induced bronchial anaphylactic reactions (BAR) in SD rats immunized with ovalbumin (OA) and alum. The animals were treated with vehicle, budesonide (BUD), dexamethasone (DEX), or hydrocortisone (HC) at various times before intravenous (i.v.) antigen challenge. The drugs were administered either intraperitoneally (i.p.) or intratracheally (i.t.); the BAR was elicited by a low or by a high challenge dose of antigen. A BAR elicited by a low challenge dose of antigen was reduced in a dose-dependent way by all GCS after i.p. administration; at 1 mg/kg, BUD and DEX significantly reduced BAR and at 50 mg/kg all three of the examined compounds inhibited the BAR by 50% or more. For BUD, maximum effect was recorded when it was given 12 h before test. There was only a slight variation in the inhibitory effects of the GCS with immunization conditions of test animals. I.t. instillation of the drugs did not markedly increase their inhibitory capacity as compared to i.p. administration. BAR elicited by a high antigen dose was at best marginally affected by the GCS when given either i.p. or i.t. Thus, antigen-induced airway reactivity in rats can be reduced by GCS treatment provided that this is performed sufficiently long before the test and that the challenge dose of antigen is not too high.
我们研究了糖皮质激素（GCS）对用卵清蛋白（OA）和明矾免疫的SD大鼠抗原诱导的支气管过敏反应（BAR）的影响。在静脉内（i.v.）抗原攻击前的不同时间，给动物分别用赋形剂、布地奈德（BUD）、地塞米松（DEX）或氢化可的松（HC）进行处理。药物通过腹腔内（i.p.）或气管内（i.t.）给药；低剂量或高剂量抗原激发BAR。腹腔注射后，所有GCS均以剂量依赖性方式降低低剂量抗原激发的BAR；在1mg/kg时，BUD和DEX显著降低BAR，在50mg/kg时，所有三种受试化合物均使BAR抑制50%或更多。对于BUD，在试验前12小时给药时记录到最大效果。GCS的抑制作用随试验动物的免疫条件仅有轻微变化。与腹腔注射相比，气管内滴注药物并未显著增加其抑制能力。当腹腔注射或气管内给药时，高剂量抗原激发的BAR最多仅受到GCS的轻微影响。因此，只要在试验前足够长的时间进行GCS治疗且抗原激发剂量不太高，大鼠抗原诱导的气道反应性就可以通过GCS治疗降低。
