Dahlbäck M
Allergy. 1981 Nov;36(8):583-95. doi: 10.1111/j.1398-9995.1981.tb01876.x.
Bronchial anaphylactic reactions, estimated as increase in intratracheal pressure, were precipitated by intravenous injections of antigen into actively sensitized SD rats. The degree of bronchial reactivity was found to depend on both the challenge dose and the immunization dose of antigen; therefore the course of the capacity to respond was recorded as a function of these variables. The degree of the bronchial anaphylactic response could be reduced by pretreatment with disodium cromoglycate, terbutaline or a new anti-allergic xanthine derivative, D 4026, in some groups of animals. The efficacy of each agent was found to depend on the dose of antigen used for sensitization and for provocation of the bronchial reaction rather than on the strength of the response. Taken together, the data suggest that more than one type of homocytotropic antibody mediates bronchial anaphylactic reactivity in the SD rat.
通过向主动致敏的SD大鼠静脉注射抗原，引发支气管过敏反应（以气管内压力升高来估计）。发现支气管反应性的程度取决于抗原的激发剂量和免疫剂量；因此，将反应能力的变化过程记录为这些变量的函数。在某些动物组中，用色甘酸二钠、特布他林或一种新的抗过敏黄嘌呤衍生物D 4026预处理可降低支气管过敏反应的程度。发现每种药物的疗效取决于用于致敏和激发支气管反应的抗原剂量，而不是反应的强度。综合来看，这些数据表明，不止一种亲同种细胞抗体介导SD大鼠的支气管过敏反应性。
