Bergeron M G, LeBel M, Charest A, Forcier J F, Morin J, Vallée F
Antimicrob Agents Chemother. 1986 Feb;29(2):379-81. doi: 10.1128/AAC.29.2.379.
The objectives of this study were to investigate the bactericidal activity in serum of cefotaxime alone or in combination with tobramycin against clinical strains and to determine the influence of tobramycin on the pharmacokinetics of cefotaxime. The peak bactericidal activity in serum of cefotaxime alone against Klebsiella oxytoca, Enterobacter aerogenes, Serratia marcescens, Pseudomonas cepacia, and Listeria monocytogenes varied between 1:4 and 1:256. Bactericidal activity could still be detected at 6 h against K. oxytoca and L. monocytogenes. The addition of tobramycin increased the bactericidal activity of cefotaxime against E. aerogenes from 1:16 to 1:128 (P less than 0.01). Cefotaxime recovery from urine was significantly decreased when tobramycin was added. Our data are comparable with those of other investigators who have shown a limited increase in the bactericidal activity of cefotaxime when aminoglycosides are added.
本研究的目的是调查头孢噻肟单独使用或与妥布霉素联合使用时对临床菌株的血清杀菌活性，并确定妥布霉素对头孢噻肟药代动力学的影响。头孢噻肟单独对产酸克雷伯菌、产气肠杆菌、粘质沙雷氏菌、洋葱伯克霍尔德菌和单核细胞增生李斯特菌的血清峰值杀菌活性在1:4至1:256之间变化。6小时时对产酸克雷伯菌和单核细胞增生李斯特菌仍可检测到杀菌活性。添加妥布霉素使头孢噻肟对产气肠杆菌的杀菌活性从1:16提高到1:128（P小于0.01）。添加妥布霉素时，尿液中头孢噻肟的回收率显著降低。我们的数据与其他研究者的数据相当，他们表明添加氨基糖苷类药物时头孢噻肟的杀菌活性仅有限增加。
