氨曲南及头孢噻肟单用或联用妥布霉素对铜绿假单胞菌和金黄色葡萄球菌的血清杀菌活性
Serum bactericidal activity of moxalactam and cefotaxime with and without tobramycin against Pseudomonas aeruginosa and Staphylococcus aureus.
作者信息
Lagast H, Zinner S H, Klastersky J
出版信息
Antimicrob Agents Chemother. 1981 Oct;20(4):539-41. doi: 10.1128/AAC.20.4.539.
Abstract
Serum bactericidal activity was determined against 10 strains each of Pseudomonas aeruginosa and Staphylococcus aureus in serum from volunteers 1 and 6 h after intravenous infusion of cefotaxime, tobramycin, and the combination; or of moxalactam, tobramycin, and the combination. High serum bactericidal activity against P. aeruginosa was found significantly more frequently with moxalactam plus tobramycin than with cefotaxime, moxalactam, and tobramycin alone or with cefotaxime plus tobramycin.
摘要
在静脉输注头孢噻肟、妥布霉素及其联合用药；或拉氧头孢、妥布霉素及其联合用药1小时和6小时后，测定志愿者血清对10株铜绿假单胞菌和10株金黄色葡萄球菌的杀菌活性。结果发现，拉氧头孢加妥布霉素联合用药组对铜绿假单胞菌的血清杀菌活性显著高于单独使用头孢噻肟、拉氧头孢、妥布霉素，或头孢噻肟加妥布霉素组。
相似文献
1
Serum bactericidal activity of moxalactam and cefotaxime with and without tobramycin against Pseudomonas aeruginosa and Staphylococcus aureus.氨曲南及头孢噻肟单用或联用妥布霉素对铜绿假单胞菌和金黄色葡萄球菌的血清杀菌活性
Antimicrob Agents Chemother. 1981 Oct;20(4):539-41. doi: 10.1128/AAC.20.4.539.
2
Comparative synergistic activity of cefoperazone, cefotaxime, moxalactam, and carbenicillin, combined with tobramycin, against Pseudomonas aeruginosa.头孢哌酮、头孢噻肟、拉氧头孢和羧苄西林与妥布霉素联合应用对铜绿假单胞菌的比较协同活性。
Antimicrob Agents Chemother. 1981 Feb;19(2):332-4. doi: 10.1128/AAC.19.2.332.
3
Procedure for assay of tobramycin in serum containing moxalactam.含拉氧头孢血清中妥布霉素的测定方法
Antimicrob Agents Chemother. 1981 May;19(5):934-6. doi: 10.1128/AAC.19.5.934.
4
Moxalactam-tobramycin-resistant Pseudomonas aeruginosa isolates in patients with cystic fibrosis.
Clin Pediatr (Phila). 1983 Sep;22(9):628-30. doi: 10.1177/000992288302200907.
5
Comparison of cefoperazone, cefotaxime, and moxalactam (LY127935) against aerobic gram-negative bacilli.头孢哌酮、头孢噻肟和拉氧头孢（LY127935）对需氧革兰氏阴性杆菌的比较。
Antimicrob Agents Chemother. 1980 Mar;17(3):488-93. doi: 10.1128/AAC.17.3.488.
6
Moxalactam (LY127935), a new semisynthetic 1-oxa-beta-lactam antibiotic with remarkable antimicrobial activity: in vitro comparison with cefamandole and tobramycin.莫西拉酸（LY127935），一种新型半合成1-氧杂-β-内酰胺抗生素，具有显著的抗菌活性：与头孢孟多和妥布霉素的体外比较。
Antimicrob Agents Chemother. 1980 Apr;17(4):750-6. doi: 10.1128/AAC.17.4.750.
7
Assessment of serum bactericidal activity after administration of cefoperazone, cefotaxime, ceftizoxime, and moxalactam to healthy subjects.对健康受试者给予头孢哌酮、头孢噻肟、头孢唑肟和拉氧头孢后血清杀菌活性的评估。
Antimicrob Agents Chemother. 1985 Jul;28(1):55-7. doi: 10.1128/AAC.28.1.55.
8
9
Correlation of predicted serum bactericidal activities and values measured in volunteers.预测的血清杀菌活性与志愿者体内测量值的相关性。
Eur J Clin Microbiol. 1986 Feb;5(1):88-92. doi: 10.1007/BF02013475.
10
Bactericidal and synergistic activity of moxalactam alone and in combination with gentamicin against Pseudomonas aeruginosa.羟羧氧酰胺菌素单独及与庆大霉素联合对铜绿假单胞菌的杀菌及协同活性。
Antimicrob Agents Chemother. 1983 Jan;23(1):179-81. doi: 10.1128/AAC.23.1.179.
引用本文的文献
1
Cefotaxime. A review of its antibacterial activity, pharmacological properties and therapeutic use.头孢噻肟：抗菌活性、药理特性及治疗用途综述
Drugs. 1983 Mar;25(3):223-89. doi: 10.2165/00003495-198325030-00001.
2
Bactericidal and synergistic activity of moxalactam alone and in combination with gentamicin against Pseudomonas aeruginosa.羟羧氧酰胺菌素单独及与庆大霉素联合对铜绿假单胞菌的杀菌及协同活性。
Antimicrob Agents Chemother. 1983 Jan;23(1):179-81. doi: 10.1128/AAC.23.1.179.
3
Emergence of resistance to beta-lactam and aminoglycoside antibiotics during moxalactam therapy of Pseudomonas aeruginosa infections.在使用羟羧氧酰胺菌素治疗铜绿假单胞菌感染期间，对β-内酰胺类和氨基糖苷类抗生素产生耐药性。
Antimicrob Agents Chemother. 1982 Dec;22(6):1037-41. doi: 10.1128/AAC.22.6.1037.
4
Cephalosporins in gram-positive infections.革兰氏阳性菌感染中的头孢菌素
Drugs. 1987;34 Suppl 2:121-34. doi: 10.2165/00003495-198700342-00010.
5
Comparative study of serum bactericidal activity of cefotaxime alone or in combination with tobramycin.头孢噻肟单独使用或与妥布霉素联合使用时血清杀菌活性的比较研究。
Antimicrob Agents Chemother. 1986 Feb;29(2):379-81. doi: 10.1128/AAC.29.2.379.
6
Serum bactericidal test in volunteers--a review.志愿者血清杀菌试验——综述
Eur J Clin Microbiol. 1986 Feb;5(1):71-8. doi: 10.1007/BF02013473.
7
Evaluation of novel antipseudomonal drugs using the serum bactericidal activity test.
Eur J Clin Microbiol. 1986 Feb;5(1):119-23. doi: 10.1007/BF02013481.
本文引用的文献
1
Comparison of in vitro activity of moxalactam (LY127935) with cefazolin, amikacin, tobramycin, carbenicillin, piperacillin, and ticarcillin against 420 blood culture isolates.羟羧氧酰胺菌素（LY127935）与头孢唑林、阿米卡星、妥布霉素、羧苄西林、哌拉西林及替卡西林对420例血培养分离菌的体外活性比较
Antimicrob Agents Chemother. 1980 Mar;17(3):412-6. doi: 10.1128/AAC.17.3.412.
2
Pharmacology of a new 1-oxa-beta-lactam (LY127935) in normal volunteers.新型1-氧杂-β-内酰胺（LY127935）在正常志愿者中的药理学研究。
Antimicrob Agents Chemother. 1980 Feb;17(2):226-8. doi: 10.1128/AAC.17.2.226.
3
Activity of cefotaxime-aminoglycoside combinations against aminoglycoside-resistant Pseudomonas.头孢噻肟-氨基糖苷类联合用药对耐氨基糖苷类铜绿假单胞菌的活性
Antimicrob Agents Chemother. 1980 Mar;17(3):474-6. doi: 10.1128/AAC.17.3.474.
4
Cefotaxime kinetics after intravenous and intramuscular injection of single and multiple doses.单次和多次静脉及肌内注射头孢噻肟后的动力学
Clin Pharmacol Ther. 1980 May;27(5):677-85. doi: 10.1038/clpt.1980.96.
5
Simplified, accurate method for antibiotic assay of clinical specimens.临床标本抗生素检测的简化、准确方法。
Appl Microbiol. 1966 Mar;14(2):170-7. doi: 10.1128/am.14.2.170-177.1966.
6
Antibacterial activity in serum and urine as a therapeutic guide in bacterial infections.血清和尿液中的抗菌活性作为细菌感染治疗的指导依据。
J Infect Dis. 1974 Feb;129(2):187-93. doi: 10.1093/infdis/129.2.187.
7
LY127935, a novel oxa-beta-lactam: an in vitro comparison with other beta-lactam antibiotics.LY127935，一种新型氧杂β-内酰胺：与其他β-内酰胺抗生素的体外比较
Antimicrob Agents Chemother. 1979 Sep;16(3):341-5. doi: 10.1128/AAC.16.3.341.
8
In vitro of cefotaxime against cephalothin-resistant clinical isolates.头孢噻肟对耐头孢噻吩临床分离株的体外研究。
Antimicrob Agents Chemother. 1979 Jul;16(1):109-11. doi: 10.1128/AAC.16.1.109.
9
Serum dilution test for bactericidal activity. II. Standardization and correlation with antimicrobial assays and susceptibility tests.
J Infect Dis. 1977 Aug;136(2):196-204. doi: 10.1093/infdis/136.2.196.
10
Significance of antimicrobial synergism for the outcome of gram negative sepsis.
Am J Med Sci. 1977 Mar-Apr;273(2):157-67. doi: 10.1097/00000441-197703000-00005.
Zotero 插件