Alinejad Faranak, Momeni Mahnoush, Fatemi Mohammad Javad, Dahmardehei Mostafa, Naderi Soheila, Akhoondinasab Mohammad Reza, Zayedly Masoume, Mahboubi Omid, Rahbar Hossein
Department of Infectious Diseases, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
Department of General Surgery, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
Iran J Microbiol. 2018 Dec;10(6):378-384.
This study was conducted to compare the effect of acticoat and agcoat dressing (2 types of silver nano-crystalline dressings) in the treatment of burn wounds. Infection is one of the most important causes of death in patients with major burn. Despite using different prevention methods, including prophylaxis antibiotics with broad-spectrum antibiotics, no method has been found to prevent this dangerous complication for burn patients. Topical silver sulfadiazine is one of the best topical antibiotics in infection control of burn wounds, and other forms of AG dressings are also useful. Their advantages are slow releasing, further-half-life, less frequent dressing change, and less pain during replacement.
In this study, 30 patients with infected full thickness burn wound were selected. The patients' age range was 18-85 years, with the mean age of 39.7-17.27. Every patient's wound was divided into 2 parts randomly, one part was dressed with agcoat and the other with acticoat. Sampling of the 2 parts was done before dressing and after the third and seventh day of dressing.
The positive outcome of the first day culturing before silver dressing was 80% and 76.7% for agcoat and acticoat, respectively. However, on the third day, it decreased to 30% and 33.3%, respectively. On the seventh day, it further decreased to 20% in both groups, and the percentage of bacterial growth reduction was not significant.
Based on the results of this study, silver agcoat dressing was as effective as acticoat dressing in preventing burn wound infection.
本研究旨在比较Acticoat和Agcoat敷料（两种纳米银晶体敷料）在治疗烧伤创面中的效果。感染是大面积烧伤患者死亡的最重要原因之一。尽管采用了不同的预防方法，包括使用广谱抗生素进行预防性治疗，但尚未找到预防烧伤患者这种危险并发症的方法。磺胺嘧啶银是烧伤创面感染控制中最好的局部用抗生素之一，其他形式的AG敷料也很有用。它们的优点是缓释、半衰期长、换药频率低以及换药时疼痛较轻。
本研究选取了30例全层感染烧伤创面患者。患者年龄范围为18 - 85岁，平均年龄为39.7 - 17.27岁。每位患者的创面随机分为两部分，一部分用Agcoat敷料包扎，另一部分用Acticoat敷料包扎。在包扎前以及包扎后第3天和第7天对两部分进行取样。
银敷料包扎前第一天培养的阳性结果，Agcoat和Acticoat分别为80%和76.7%。然而，在第三天，分别降至30%和33.3%。在第七天，两组均进一步降至20%，细菌生长减少的百分比无显著差异。
基于本研究结果，Agcoat银敷料在预防烧伤创面感染方面与Acticoat敷料效果相同。
