Faculty of Iranian Traditional Medicine and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Phytother Res. 2019 May;33(5):1404-1412. doi: 10.1002/ptr.6331. Epub 2019 Mar 14.
Preclinical studies have shown beneficial effects of black seed (Nigella sativa L.) in the prevention and treatment of renal stones. Hence, we designed a study to evaluate the renal-stone-dissolving efficacy of black seed. Sixty patients with renal stones were randomly enrolled in two arms of a randomized, triple-blind, placebo-controlled, clinical trial. The patients were treated by black seed capsules (500 mg) or placebo two times per day for 10 weeks. Patients were assessed in terms of size of renal stones by using sonography before and after intervention. In the black seed group, 44.4% of patients excreted their stones completely, and the size of the stones remained unchanged and decreased in 3.7% and 51.8% of patients, respectively. In contrast, in the placebo group, 15.3% of the patients excreted their stones completely, 11.5% had reduction in stone size, 15.3% had increase in stone size, and 57.6% had no change in their stone size. The difference in the mean size of renal stones after the study was significant between the two groups (p < 0.05). N. sativa L., as compared with placebo, is demonstrated to have significant positive effects on disappearance or reduction of size of kidney stones.
临床前研究表明，黑种草（Nigella sativa L.）在预防和治疗肾结石方面具有有益作用。因此，我们设计了一项研究来评估黑种草溶解肾结石的功效。60 名肾结石患者被随机分为两组，进行随机、三盲、安慰剂对照临床试验。患者每天服用黑种草胶囊（500mg）或安慰剂两次，持续 10 周。在干预前后，通过超声检查评估患者肾结石的大小。在黑种草组中，44.4%的患者完全排出了结石，3.7%和 51.8%的患者的结石大小保持不变和减小。相比之下，在安慰剂组中，15.3%的患者完全排出了结石，11.5%的患者结石大小减小，15.3%的患者结石大小增大，57.6%的患者结石大小没有变化。研究后两组肾结石的平均大小差异有统计学意义（p < 0.05）。与安慰剂相比，黑种草（N. sativa L.）对肾结石的消失或减小具有显著的积极作用。
