Javidi Najmeh, Mazloum Khorasani Zahra, Salari Roshanak, Niroumand Shabnam, Yousefi Mahdi
Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Avicenna J Phytomed. 2024 May-Jun;14(3):325-337. doi: 10.22038/AJP.2024.23984.
Hypothyroidism is characterized by insufficient production of thyroxine by the thyroid gland. Levothyroxine may not fully alleviate patients' symptoms. This study aimed to assess the impact of a herbal product on weight, body mass index (BMI), thyroid hormones, lipid profile, fasting blood sugar (FBS), depression, and quality-of-life scores in patients.
72 patients with primary hypothyroidism, aged between 20 and 65 years old, participated in the trial and they were randomly allocated into two groups. The intervention group received the herbal powder containing L., L., and L. while the control group received Avicel for 8 weeks.
Treatment with the herbal product resulted in statistically significant reductions in anthropometric variables such as BMI (p=0.03), hip circumference (HC) (p=0.008), waist circumference (WC) (p<0.001), and waist-to-hip circumference ratio (WHR) (p=0.003) in the intervention group in comparison between intervention and control groups. However, the decrease in weight was not statistically significant (p=0.08) in the intervention group compared the control group. In comparison between two groups, the depression score exhibited a statistically significant decrease in the intervention (p=0.001) and control groups (p=0.01), while there was a statistically significant increase in the quality-of-life score only in the intervention group (p<0.001) in comparison between intervention and control groups.
The results indicate the potential beneficial effects of the herbal product on anthropometric variables in patients. Furthermore, the intervention yielded significant improvements in depression symptoms and quality-of-life scores among the patients.
甲状腺功能减退症的特征是甲状腺产生的甲状腺素不足。左甲状腺素可能无法完全缓解患者的症状。本研究旨在评估一种草药产品对患者体重、体重指数（BMI）、甲状腺激素、血脂谱、空腹血糖（FBS）、抑郁和生活质量评分的影响。
72例年龄在20至65岁之间的原发性甲状腺功能减退症患者参与了试验，他们被随机分为两组。干预组服用含有[具体植物名称1]、[具体植物名称2]和[具体植物名称3]的草药粉，而对照组服用微晶纤维素，为期8周。
与对照组相比，干预组使用该草药产品治疗后，人体测量学变量如BMI（p = 0.03）、臀围（HC）（p = 0.008）、腰围（WC）（p < 0.001）和腰臀比（WHR）（p = 0.003）有统计学意义的降低。然而，与对照组相比，干预组体重的下降无统计学意义（p = 0.08）。两组比较，干预组（p = 0.001）和对照组（p = 0.01）的抑郁评分均有统计学意义的下降，而干预组与对照组比较，仅干预组的生活质量评分有统计学意义的提高（p < 0.001）。
结果表明该草药产品对患者人体测量学变量有潜在的有益作用。此外，该干预措施使患者的抑郁症状和生活质量评分有显著改善。
