先天免疫、炎症与肿瘤进展：双刃剑。
Innate immunity, inflammation and tumour progression: double-edged swords.
机构信息
Humanitas Clinical and Research Center - IRCCS, via Manzoni 56, 20089, Rozzano, (Mi), Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele Milan, Italy.
出版信息
J Intern Med. 2019 May;285(5):524-532. doi: 10.1111/joim.12886. Epub 2019 Mar 14.
Abstract
Components of the cellular and the humoral arm of the immune system are essential elements of the tumour microenvironment (TME). The TME includes tumour-associated macrophages which have served as a paradigm for the cancer-promoting inflammation. Cytokines, IL-1 in particular, and complement have emerged as important players in tumour promotion. On the other hand, myeloid cells, innate lymphoid cells and complement have the potential, if unleashed, to mediate anticancer resistance. Targeting checkpoints restraining innate immunity, macrophages and natural killer (NK) cells in particular holds promise as a therapeutic strategy.
摘要
细胞和体液免疫的组成部分是肿瘤微环境 (TME) 的重要元素。TME 包括肿瘤相关巨噬细胞，它们已成为促进癌症炎症的典范。细胞因子，特别是白细胞介素 1 (IL-1) 和补体，已成为肿瘤促进的重要参与者。另一方面，如果释放，髓样细胞、固有淋巴细胞和补体有可能介导抗癌耐药性。作为一种治疗策略，靶向限制先天免疫的检查点、巨噬细胞和自然杀伤 (NK) 细胞具有广阔的前景。
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