Saint Louis University School of Medicine, St. Louis, MO, USA.
Am Fam Physician. 2019 Mar 15;99(6):370-375.
With declining mortality rates, the number of breast cancer survivors is increasing. Ongoing care after breast cancer treatment is often provided by primary care physicians. This care includes surveillance for cancer recurrence with a history and physical examination every three to six months for the first three years after treatment, every six to 12 months for two more years, and annually thereafter. Mammography is performed annually. Magnetic resonance imaging of the breast is not indicated unless patients are at high risk of recurrence, such as having a hereditary cancer syndrome. Many breast cancer survivors experience long-term sequelae from the disease or treatment. Premature menopause with hot flashes can occur and is managed with pharmacologic and nonpharmacologic treatments. Vaginal dryness is treated with vaginal lubricants and gels. Because cardiotoxicity from chemotherapy is possible, clinicians should be alert for this complication and perform echocardiography if appropriate. Impaired cognition after chemotherapy is also common; treatment includes cognitive rehabilitation therapy. Patients with treatment-induced menopause develop decreased bone density and should receive dual energy x-ray absorptiometry and pharmacologic and nonpharmacologic therapies. Others experience lymphedema, often best managed with weight loss and complex decongestive therapy. Some women develop chronic pain, which is treated by addressing psychological factors and with appropriate pharmacologic therapy.
随着死亡率的下降,乳腺癌幸存者的数量正在增加。乳腺癌治疗后的持续护理通常由初级保健医生提供。这种护理包括通过病史和体格检查进行癌症复发的监测,治疗后前三年每三到六个月一次,接下来两年每六到十二个月一次,此后每年一次。每年进行乳房 X 光检查。除非患者有复发的高风险,如遗传性癌症综合征,否则不建议进行乳房磁共振成像。许多乳腺癌幸存者会经历疾病或治疗带来的长期后遗症。可能会出现过早绝经和热潮红,可以通过药物和非药物治疗来管理。阴道干燥可以用阴道润滑剂和凝胶治疗。由于化疗可能导致心脏毒性,临床医生应警惕这种并发症,并在适当情况下进行超声心动图检查。化疗后认知受损也很常见;治疗包括认知康复治疗。因治疗导致绝经的患者骨密度降低,应接受双能 X 线吸收法和药物及非药物治疗。其他人会出现淋巴水肿,通常通过减轻体重和复杂的消肿治疗来最好地进行管理。一些女性会出现慢性疼痛,通过解决心理因素和适当的药物治疗来治疗。