Durdevic Ljiljana, Robert Hadrien M L, Wattellier Benoit, Monneret Serge, Baffou Guillaume
Institut Fresnel, CNRS, Aix Marseille Univ, Centrale Marseille, Marseille, France.
PHASICS S.A., Parc technologique de Saint Aubin, Route de l'Orme des Merisiers, 91190, Saint Aubin, France.
Sci Rep. 2019 Mar 15;9(1):4644. doi: 10.1038/s41598-019-40382-3.
Heating on the microscale using focused lasers gave rise to recent applications, e.g., in biomedicine, biology and microfluidics, especially using gold nanoparticles as efficient nanoabsorbers of light. However, such an approach naturally leads to nonuniform, Gaussian-like temperature distributions due to the diffusive nature of heat. Here, we report on an experimental means to generate arbitrary distributions of temperature profiles on the micrometric scale (e.g. uniform, linear, parabolic, etc) consisting in illuminating a uniform gold nanoparticle distribution on a planar substrate using spatially contrasted laser beams, shaped using a spatial light modulator (SLM). We explain how to compute the light pattern and the SLM interferogram to achieve the desired temperature distribution, and demonstrate the approach by carrying out temperature measurements using quantitative wavefront sensing.
利用聚焦激光进行微尺度加热催生了近期的一些应用,例如在生物医学、生物学和微流体领域,特别是使用金纳米颗粒作为高效的光纳米吸收体。然而,由于热的扩散性质,这种方法自然会导致不均匀的、类似高斯分布的温度分布。在此,我们报告一种在微米尺度上生成任意温度分布轮廓(例如均匀、线性、抛物线等)的实验方法,该方法是通过使用空间光调制器(SLM)塑造的具有空间对比度的激光束照射平面衬底上均匀分布的金纳米颗粒来实现的。我们解释了如何计算光图案和SLM干涉图以实现所需的温度分布,并通过使用定量波前传感进行温度测量来演示该方法。