Oppenheimer S, Hoffbrand B I
Can J Neurol Sci. 1986 May;13(2):129-32. doi: 10.1017/s0317167100036064.
The optic neuritis of systemic lupus erythematosus (S.L.E.) more frequently results in the persistence of a central scotoma or complete blindness after a single attack than demyelinating optic neuritis, although the initial clinical presentations may be identical. A significant number of patients, however, recover normal vision. Optic neuritis may be the presenting symptom of S.L.E. and as myelopathy may also occur in the course of the disease, confusion with multiple sclerosis may result, especially if there are no arthritic, cutaneous nor visceral manifestations. We report a case of lupus optic neuritis associated with anticardiolipin antibodies and a circulating lupus anticoagulant and suggest these may be a marker for vasculitic optic neuritis and play a role in its aetiology.
系统性红斑狼疮（S.L.E.）所致的视神经炎，相较于脱髓鞘性视神经炎，虽初始临床表现可能相同，但单次发作后更常导致中心暗点持续存在或完全失明。然而，相当数量的患者视力可恢复正常。视神经炎可能是S.L.E.的首发症状，且由于脊髓病也可能在该疾病过程中出现，可能会导致与多发性硬化混淆，尤其是在无关节炎、皮肤及内脏表现时。我们报告一例与抗心磷脂抗体及循环狼疮抗凝物相关的狼疮性视神经炎病例，并提示这些可能是血管炎性视神经炎的标志物，且在其病因学中起作用。
