Hong C Y, Huang J J, Chiang B N, Wei Y H
Contraception. 1986 Mar;33(3):301-6. doi: 10.1016/0010-7824(86)90021-1.
The inhibitory effect of five ionophores, namely, A23187, nonactin, nigericin, monensin and m-chlorocarbonyl cyanide phenylhydrazone, on human sperm motility were measured with a trans-membrane migration method. The concentrations of A23187 and nigericin that decreased sperm motility to 50% of control were 20 microM (10.5 mg/l) and 8 microM (5.8 mg/l), respectively. Because these two ionophores were more potent than previously reported membrane-active sperm-immobilizing agents, we propose that ionophores could be a new category of vaginal contraceptive if a pharmaceutical preparation that is safe to be administered in vivo can be developed.
采用跨膜迁移法测定了5种离子载体（即A23187、无活菌素、尼日利亚菌素、莫能菌素和间氯羰基氰化物苯腙）对人精子活力的抑制作用。使精子活力降低至对照值50%的A23187和尼日利亚菌素的浓度分别为20微摩尔/升（10.5毫克/升）和8微摩尔/升（5.8毫克/升）。由于这两种离子载体比先前报道的膜活性精子固定剂更有效，我们提出，如果能开发出一种在体内给药安全的药物制剂，离子载体可能成为一类新型阴道避孕药。
