RNA 表观遗传学与心血管疾病。
RNA epigenetics and cardiovascular diseases.
机构信息
Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA.
Cardiovascular Disease Prevention & Resilience Hub, Institute of Genetic Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.
出版信息
J Mol Cell Cardiol. 2019 Apr;129:272-280. doi: 10.1016/j.yjmcc.2019.03.010. Epub 2019 Mar 14.
Cardiovascular disease (CVD) remains the leading cause of death in the Western world. Despite advances in the prevention and in the management of CVD, the role of RNA epigenetics in the cardiovascular system has been until recently unexplored. The rapidly expanding research field of RNA modifications has introduced a novel layer of gene regulation in mammalian cells. RNA modifications may control all aspects of RNA metabolism, and their study reveals previously unrecognized regulatory pathways that may determine gene expression at a post-transcriptional level. Understanding the role of RNA modifications in CVD may lead towards a better understanding of disease mechanisms and the development of novel biomarkers or therapeutic strategies. In this review, we highlight the most recent and major reports in the field of RNA methylation and adenosine to inosine RNA editing related to the cardiovascular field and we discuss how this breakthrough will advance the field of precision medicine.
心血管疾病（CVD）仍然是西方世界的主要死亡原因。尽管在 CVD 的预防和管理方面取得了进展，但 RNA 表观遗传学在心血管系统中的作用直到最近才被探索。RNA 修饰这一快速发展的研究领域为哺乳动物细胞中的基因调控引入了一个新的层面。RNA 修饰可以控制 RNA 代谢的各个方面，它们的研究揭示了以前未被认识的调节途径，这些途径可能在转录后水平决定基因表达。了解 RNA 修饰在 CVD 中的作用可能有助于更好地了解疾病机制，并开发新的生物标志物或治疗策略。在这篇综述中，我们强调了与心血管领域相关的 RNA 甲基化和腺苷到肌苷 RNA 编辑领域的最新和主要报告，并讨论了这一突破将如何推动精准医学领域的发展。
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