Horny H P, Parwaresch M R, Kaiserling E, Müller K, Olbermann M, Mainzer K, Lennert K
J Clin Pathol. 1986 Jun;39(6):596-602. doi: 10.1136/jcp.39.6.596.
A 74 year old woman presented with a primary subglottic tumour. Neither cutaneous mastocytosis (urticaria pigmentosa) nor spread to the bone marrow, liver, or spleen were detected. About two years after initial manifestation of the tumour nodular skin metastases appeared, as well as local recurrence in the larynx. Despite chemotherapy and radiation the disease progressed and was fatal. The terminal phase was characterised by generalisation of the mast cell tumour with diffuse infiltration of bone marrow and, shortly before death, leukaemic transformation. The patient died four years after onset of disease with symptoms of a hemorrhagic diathesis. As far as we know this is the first case of mast cell sarcoma to be reported in man.
一名74岁女性因原发性声门下肿瘤就诊。未检测到皮肤肥大细胞增多症（色素性荨麻疹），也未发现肿瘤扩散至骨髓、肝脏或脾脏。肿瘤最初出现约两年后，出现了结节性皮肤转移以及喉部局部复发。尽管进行了化疗和放疗，病情仍进展并导致死亡。终末期的特征是肥大细胞瘤广泛播散，骨髓弥漫性浸润，临死前发生白血病转化。患者在疾病发作四年后死于出血素质症状。据我们所知，这是首例人类肥大细胞肉瘤的报告病例。
