一种与克隆型受体β链相关的新的HLA连锁T细胞膜分子与T3相关。
A new HLA-linked T cell membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3.
作者信息
Bushkin Y, Posnett D N, Pernis B, Wang C Y
出版信息
J Exp Med. 1986 Aug 1;164(2):458-73. doi: 10.1084/jem.164.2.458.
Abstract
The 38 kD molecule is noncovalently associated with beta 2 microglobulin (beta 2m)-free HLA heavy chain-like molecule, and thus forms a second heterodimer distinct from the clonotypic alpha/beta T cell receptor expressed by the same clone of leukemia cells. This second heterodimer (38 kD/HLA) is variably expressed and appears to be associated with the T3 molecule. We suggest, therefore, that it has a functional role in T cell activation.
摘要
38kD分子与无β2微球蛋白（β2m）的HLA重链样分子非共价结合，从而形成一种不同于同一白血病细胞克隆所表达的克隆型α/βT细胞受体的第二异二聚体。这种第二异二聚体（38kD/HLA）表达可变，且似乎与T3分子相关。因此，我们认为它在T细胞激活中具有功能作用。
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