Basile Stefano, Pinelli Sara, Micelli Elisabetta, Caretto Marta, Benedetti Panici Pierluigi
Maternal and Child Health Department, Division of Obstetrics and Gynecology 2, Pisa University Hospital, Pisa, Italy.
Department of Gynecologic-Obstetrical and Urologic Sciences, Sapienza University Hospital, Rome, Italy.
Biomed Res Int. 2019 Feb 11;2019:9185059. doi: 10.1155/2019/9185059. eCollection 2019.
Umbilical cord milking is a procedure in which clamped or unclamped umbilical cord is grasped, and blood is pushed ("stripped") two to four times towards the newborn, in a rapid time frame, usually within 20 seconds. The target of umbilical cord milking is to provide infants with their whole potential blood volume-of which they are deprived when early cord clamping is carried out-completing placental transfusion in a shorter time than delayed cord clamping. The aim of this narrative review is to analyse the literature regarding umbilical cord milking in term and late-preterm infants and to assess all possible benefits and limits of this procedure in clinical practice, especially in comparison to immediate and delayed cord clamping.
We analysed literature data concerning maternal, as well as neonatal, outcomes for term and late-preterm (gestational age ≥ 34 weeks) newborns who received umbilical cord milking.
Most studies show comparable benefits for both umbilical cord milking and delayed cord clamping, especially in terms of haematological parameters when compared to immediate cord clamping. Umbilical cord milking may be a feasible procedure also for newborns requiring resuscitation.
Literature data concerning positive effects of umbilical cord milking are encouraging and suggest that umbilical cord milking may be a quick and effective method to provide placental transfusions to depressed infants. However, the lack of standardised procedures and the variation in evaluated outcomes as well as the limited number of patients enrolled in trials, along with the retrospective nature of some of them, prevent recommending umbilical cord milking as a routine procedure.
脐带挤血是一种操作,即抓住已夹紧或未夹紧的脐带,在较短时间内(通常在20秒内)将血液快速向新生儿方向推挤(“挤出”)两到四次。脐带挤血的目的是为婴儿提供其全部潜在血容量——早期脐带夹紧会使婴儿失去这些血容量——并在比延迟脐带夹紧更短的时间内完成胎盘输血。本叙述性综述的目的是分析有关足月儿和晚期早产儿脐带挤血的文献,并评估该操作在临床实践中的所有可能益处和局限性,特别是与立即脐带夹紧和延迟脐带夹紧相比。
我们分析了有关接受脐带挤血的足月儿和晚期早产儿(胎龄≥34周)的母亲及新生儿结局的文献数据。
大多数研究表明,脐带挤血和延迟脐带夹紧的益处相当,尤其是与立即脐带夹紧相比,在血液学参数方面。脐带挤血对于需要复苏的新生儿可能也是一种可行的操作。
有关脐带挤血积极作用的文献数据令人鼓舞,表明脐带挤血可能是一种为情况不佳的婴儿进行胎盘输血的快速有效方法。然而,缺乏标准化程序、评估结局的差异、试验纳入患者数量有限以及部分研究的回顾性性质,使得无法推荐将脐带挤血作为常规操作。