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中国38家实验室间细胞遗传学剂量测定的实验室间比对

Laboratory Intercomparison of Cytogenetic Dosimetry Among 38 Laboratories in China.

作者信息

Pan Yan, Ruan Jianlei, Gao Gang, Wu Lina, Piao Chunnan, Liu Jianxiang

机构信息

China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, China.

出版信息

Dose Response. 2019 Mar 12;17(1):1559325819833473. doi: 10.1177/1559325819833473. eCollection 2019 Jan-Mar.

DOI:10.1177/1559325819833473
PMID:30890901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6416682/
Abstract

A nationwide intercomparison exercise for estimating the irradiated dose was organized by the National Institute for Radiological Protection, Center for Disease Control and Prevention of China. Thirty-eight laboratories participated in this program. The main objective of this intercomparison exercise was to compare the participants' ability of operation and dose assessment basing on the frequencies of dicentrics and centric rings. Whole blood samples were irradiated with different dosages of Co γ-rays. Each laboratory collected 2 blind samples and prepared the slides independently. All participants presented the estimated dose reports within 30 days. The doses assessed by the participants were acceptable within the reference dose of ±20%. The mean absolute difference of estimated dose relative to the reference dose was calculated, which reflected the overall accuracy of dose estimates for each laboratory. The overall estimation results of blind blood samples for intercomparison showed a good agreement with the reference dose for each sample, with nearly 75% of the participants producing acceptable results.

摘要

中国疾病预防控制中心辐射防护与核安全医学所组织了一次全国性的估算辐照剂量的比对活动。38个实验室参与了该项目。这次比对活动的主要目的是基于双着丝粒体和着丝粒环的频率,比较参与者的操作能力和剂量评估能力。用不同剂量的钴γ射线照射全血样本。每个实验室收集2个盲样并独立制备玻片。所有参与者在30天内提交估算剂量报告。参与者评估的剂量在参考剂量的±20%范围内是可接受的。计算了相对于参考剂量的估算剂量的平均绝对差值,其反映了每个实验室剂量估算的总体准确性。比对盲血样本的总体估算结果与每个样本的参考剂量显示出良好的一致性,近75%的参与者得出了可接受的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7239/6416682/af87dc9d64d0/10.1177_1559325819833473-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7239/6416682/1a079e8ee164/10.1177_1559325819833473-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7239/6416682/af87dc9d64d0/10.1177_1559325819833473-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7239/6416682/1a079e8ee164/10.1177_1559325819833473-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7239/6416682/af87dc9d64d0/10.1177_1559325819833473-fig2.jpg

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