细胞外囊泡治疗神经疾病的潜力
Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders.
作者信息
Galieva Luisa R, James Victoria, Mukhamedshina Yana O, Rizvanov Albert A
机构信息
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
School of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom.
出版信息
Front Neurosci. 2019 Mar 5;13:163. doi: 10.3389/fnins.2019.00163. eCollection 2019.
The use of extracellular vesicles (EVs) as cell free therapy is a promising approach to stimulate tissue regeneration including that of the nervous system. EVs transfer bioactive proteins and lipids, RNA and microRNAs, which play a relevant role in EV-mediated intercellular communication. The immunomodulatory, anti-inflammatory, and neuroprotective effects of mesenchymal stem cells-derived EVs have been well studied, knowledge of this paracrine mechanism and the availability of these cells, positions mesenchymal stem cells as a potential source of EVs for cell free therapy for a variety of regenerative and nervous system disorders. In this review, we focus on the immunomodulatory and neuroprotective effects of stem cells-derived EVs within and models of nerve disorders.
使用细胞外囊泡（EVs）作为无细胞疗法是刺激包括神经系统在内的组织再生的一种有前景的方法。EVs 转运生物活性蛋白和脂质、RNA 和微小 RNA，它们在 EV 介导的细胞间通讯中发挥相关作用。间充质干细胞衍生的 EVs 的免疫调节、抗炎和神经保护作用已得到充分研究，对这种旁分泌机制的了解以及这些细胞的可获得性，使间充质干细胞成为用于多种再生和神经系统疾病无细胞治疗的 EVs 的潜在来源。在本综述中，我们重点关注干细胞衍生的 EVs 在神经疾病体内和体外模型中的免疫调节和神经保护作用。
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