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本文引用的文献

1
Pro-Angiogenic Actions of CMC-Derived Extracellular Vesicles Rely on Selective Packaging of Angiopoietin 1 and 2, but Not FGF-2 and VEGF.CMC 衍生细胞外囊泡的促血管生成作用依赖于血管生成素 1 和 2 的选择性包装，但不依赖于 FGF-2 和 VEGF。
Stem Cell Rev Rep. 2019 Aug;15(4):530-542. doi: 10.1007/s12015-019-09891-6.
2
Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.细胞外囊泡介导间充质基质细胞依赖性调控 B 细胞 PI3K-AKT 信号通路和肌动蛋白细胞骨架。
Front Immunol. 2019 Mar 12;10:446. doi: 10.3389/fimmu.2019.00446. eCollection 2019.
3
EP Antagonist-Elicited Extracellular Vesicles from Mesenchymal Stem Cells Rescue Cognition/Learning Deficiencies by Restoring Brain Cellular Functions.外泌体通过恢复脑细胞功能拯救认知/学习缺陷。
Stem Cells Transl Med. 2019 Jul;8(7):707-723. doi: 10.1002/sctm.18-0284. Epub 2019 Mar 19.
4
Phase I/II Trial of Liver-derived Mesenchymal Stem Cells in Pediatric Liver-based Metabolic Disorders: A Prospective, Open Label, Multicenter, Partially Randomized, Safety Study of One Cycle of Heterologous Human Adult Liver-derived Progenitor Cells (HepaStem) in Urea Cycle Disorders and Crigler-Najjar Syndrome Patients.肝源间充质干细胞治疗儿童肝脏代谢性疾病的 I/II 期临床试验：前瞻性、开放标签、多中心、部分随机、单次异体人成体肝源祖细胞（HepaStem）治疗尿素循环障碍和克里格勒-纳贾尔综合征患者的安全性研究。
Transplantation. 2019 Sep;103(9):1903-1915. doi: 10.1097/TP.0000000000002605.
5
Metabolic Syndrome Interferes with Packaging of Proteins within Porcine Mesenchymal Stem Cell-Derived Extracellular Vesicles.代谢综合征干扰猪间充质干细胞衍生细胞外囊泡中蛋白质的包装。
Stem Cells Transl Med. 2019 May;8(5):430-440. doi: 10.1002/sctm.18-0171. Epub 2019 Feb 1.
6
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.细胞外囊泡研究的最低限度信息2018（MISEV2018）：国际细胞外囊泡协会的立场声明及MISEV2014指南的更新
J Extracell Vesicles. 2018 Nov 23;7(1):1535750. doi: 10.1080/20013078.2018.1535750. eCollection 2018.
7
Mesenchymal stromal cell therapy: progress in manufacturing and assessments of potency.间充质基质细胞治疗：制造和效力评估的进展。
Cytotherapy. 2019 Mar;21(3):289-306. doi: 10.1016/j.jcyt.2018.10.014. Epub 2018 Dec 6.
8
Proteomic Signature of Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles.间质基质细胞衍生的小细胞外囊泡的蛋白质组学特征。
Proteomics. 2019 Jan;19(1-2):e1800163. doi: 10.1002/pmic.201800163. Epub 2019 Jan 4.
9
Extracellular Vesicles from Wharton's Jelly Mesenchymal Stem Cells Suppress CD4 Expressing T Cells Through Transforming Growth Factor Beta and Adenosine Signaling in a Canine Model.犬模型中，源自牙髓间充质干细胞的细胞外囊泡通过转化生长因子β和腺苷信号通路抑制 CD4 阳性 T 细胞。
Stem Cells Dev. 2019 Feb 1;28(3):212-226. doi: 10.1089/scd.2018.0097. Epub 2019 Jan 14.
10
Extracellular vesicles from pluripotent stem cell-derived mesenchymal stem cells acquire a stromal modulatory proteomic pattern during differentiation.多能干细胞来源的间充质干细胞衍生的细胞外囊泡在分化过程中获得了基质调节的蛋白质组模式。
Exp Mol Med. 2018 Sep 10;50(9):1-12. doi: 10.1038/s12276-018-0142-x.

间充质干细胞衍生细胞外囊泡的功能蛋白。

Functional proteins of mesenchymal stem cell-derived extracellular vesicles.

机构信息

Shaoxing Second Hospital, 123 Yanan Road, Shaoxing, 312000, Zhejiang, China.

The Children's Hospital of Zhejiang University School of Medicine, 3333 Binsheng Road, Hangzhou, 310051, Zhejiang, China.

出版信息

Stem Cell Res Ther. 2019 Nov 28;10(1):359. doi: 10.1186/s13287-019-1484-6.

DOI:10.1186/s13287-019-1484-6
PMID:31779700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6883709/
Abstract

Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulatory and regenerative effects of mesenchymal stem/stromal cells (MSCs) are mainly mediated by soluble paracrine factors and MSC-derived EVs (MSC-EVs). Recent studies suggest that MSC-EVs may serve as a novel and cell-free alternative to whole-cell therapies. The focus of this review is to discuss the functional proteins which facilitate the effects of MSC-EVs. The first section of the review discusses the general functions of EV proteins. Next, we describe the proteomics of MSC-EVs as compared with their parental cells. Then, the review presents the current knowledge that protein contents of MSC-EVs play an essential role in immunomodulation and treatment of various diseases. In summary, functional protein components are at least partially responsible for disease-modulating capacity of MSC-EVs.

摘要

细胞外囊泡 (EVs) 包含蛋白质、microRNAs、mRNAs、长非编码 RNA 和磷脂，是细胞间通讯的新机制。有人提出，间充质干细胞 (MSCs) 的免疫调节和再生作用主要是通过可溶性旁分泌因子和 MSC 衍生的 EVs (MSC-EVs) 介导的。最近的研究表明，MSC-EVs 可能作为一种新型的无细胞替代物用于全细胞治疗。本综述的重点是讨论促进 MSC-EVs 作用的功能性蛋白质。综述的第一部分讨论了 EV 蛋白质的一般功能。接下来，我们描述了 MSC-EVs 的蛋白质组学与亲本细胞的比较。然后，本综述介绍了目前的知识，即 MSC-EVs 的蛋白质含量在免疫调节和治疗各种疾病中起着至关重要的作用。综上所述，功能性蛋白质成分至少部分负责 MSC-EVs 的疾病调节能力。