Abudu Boya, Cohen Philip R
School of Medicine, University of California San Diego, La Jolla, USA.
Dermatology, San Diego Family Dermatology, San Diego, USA.
Cureus. 2018 Sep 14;10(9):e3304. doi: 10.7759/cureus.3304.
Juvenile nasopharyngeal angiofibroma is a vascular tumor that typically occurs in men. Vestibular schwannoma (acoustic neuroma) is a tumor affecting the vestibulocochlear nerve. A 38-year-old man with various pigmented lesions and history of juvenile nasopharyngeal angiofibroma, vestibular schwannoma, and cleft lip and cleft palate is described. Characteristics of patients with coexisting juvenile nasopharyngeal angiofibroma and vestibular schwannoma are summarized. A search, using PubMed, was performed for the following terms: acoustic, angiofibroma, blue, cleft, combined, dysplastic, juvenile, lip, nasopharyngeal, neuroma, nevus, palate, schwannoma, and vestibular. The relevant papers were obtained and their references were reviewed. Only one man with coincident juvenile nasopharyngeal angiofibroma and vestibular schwannoma has previously been described. The juvenile nasopharyngeal angiofibromas were both right-sided and diagnosed when the patients were 13 years old and 20 years old. Our patient's vestibular schwannoma was ipsilateral with his juvenile nasopharyngeal angiofibroma and incidentally diagnosed on a magnetic resonance imaging (MRI) scan that was performed to monitor for recurrent juvenile nasopharyngeal angiofibroma when he was in his 30s. The other man's vestibular schwannoma and juvenile nasopharyngeal angiofibroma were diagnosed concurrently, when he was 20 years old. The observation of a patient with cleft lip and cleft palate, various melanocytic nevi, juvenile nasopharyngeal angiofibroma, and vestibular schwannoma is unique. Although the appearance of juvenile nasopharyngeal angiofibroma and vestibular schwannoma may be coincidental, the occurrence of these tumors in the same individual may suggest an association with regards to their pathogenesis.
青少年鼻咽血管纤维瘤是一种通常发生于男性的血管性肿瘤。前庭神经鞘瘤（听神经瘤）是一种影响前庭蜗神经的肿瘤。本文描述了一名38岁男性，其患有多种色素沉着病变，并有青少年鼻咽血管纤维瘤、前庭神经鞘瘤以及唇腭裂病史。总结了同时患有青少年鼻咽血管纤维瘤和前庭神经鞘瘤患者的特征。使用PubMed搜索引擎，以“听神经、血管纤维瘤、蓝色、腭裂、合并、发育异常、青少年、唇、鼻咽、神经瘤、痣、腭、神经鞘瘤、前庭”等词进行检索。获取了相关论文并查阅了其参考文献。此前仅报道过1例同时患有青少年鼻咽血管纤维瘤和前庭神经鞘瘤的男性患者。该患者的青少年鼻咽血管纤维瘤均位于右侧，分别在13岁和20岁时确诊。我们的患者前庭神经鞘瘤与其青少年鼻咽血管纤维瘤同侧，在其30多岁时为监测复发性青少年鼻咽血管纤维瘤而进行的磁共振成像（MRI）扫描中偶然发现。另一名男性患者的前庭神经鞘瘤和青少年鼻咽血管纤维瘤在其20岁时同时确诊。观察到一名患有唇腭裂、多种黑素细胞痣、青少年鼻咽血管纤维瘤和前庭神经鞘瘤的患者情况较为独特。虽然青少年鼻咽血管纤维瘤和前庭神经鞘瘤的出现可能是巧合，但这些肿瘤在同一个体中发生可能提示在发病机制方面存在关联。
