Department of Medical Sciences, Division of Health Sciences, Campus León, University of Guanajuato, León, Guanajuato, Mexico.
Rev Endocr Metab Disord. 2019 Mar;20(1):15-25. doi: 10.1007/s11154-019-09486-z.
Neurodegeneration is traditionally viewed as a consequence of peptide accumulation in the brain, stroke and/or cerebral ischemia. Nonetheless, a number of scattered observations suggest that neurological disease and atherosclerosis may be linked by more complex mechanisms. Understanding the intricate link between atherosclerosis and neurological conditions may have a significant impact on the quality of life of the growing ageing population and of high cardiovascular risk groups in general. Epidemiological data support the notion that neurological dysfunction and atherosclerosis coexist long before any evident clinical complications of cardiovascular disease appear and may be causally linked. Baffling, often overlooked, molecular data suggest that nervous tissue-specific gene expression is relaxed specifically in the atheromatous vascular wall, and/or that a systemic dysregulation of genes involved in nervous system biology dictates a concomitant progression of neurological disease and atherosclerosis. Further epidemiological and experimental work is needed to clarify the details and clinical relevance of those complex links.
神经退行性变传统上被视为脑内肽积累、中风和/或脑缺血的结果。尽管如此，许多分散的观察结果表明，神经疾病和动脉粥样硬化之间可能存在更复杂的机制。了解动脉粥样硬化和神经疾病之间的复杂联系可能会对不断增长的老年人口以及一般的高心血管风险群体的生活质量产生重大影响。流行病学数据支持这样一种观点，即神经功能障碍和动脉粥样硬化在任何明显的心血管疾病临床并发症出现之前很久就共存，并且可能存在因果关系。令人费解的是，经常被忽视的分子数据表明，神经组织特异性基因表达在动脉粥样硬化血管壁中被特异性放松，或者涉及神经系统生物学的基因的全身性失调决定了神经疾病和动脉粥样硬化的同时进展。需要进一步的流行病学和实验工作来阐明这些复杂联系的细节和临床相关性。
