开角型青光眼和前期青光眼患者脉络膜血管指数。
Choroidal vascular index in patients with open angle glaucoma and preperimetric glaucoma.
机构信息
Department of Ophthalmology, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Korea.
出版信息
PLoS One. 2019 Mar 20;14(3):e0213336. doi: 10.1371/journal.pone.0213336. eCollection 2019.
Abstract
PURPOSE
To evaluate choroidal structural changes in glaucoma using choroidal vascularity index (CVI) compared to healthy subjects.
METHODS
This retrospective study included 56 patients with open angle glaucoma (OAG), 50 patients with preperimetric glaucoma (PPG) and 50 age-matched healthy eyes. Choroidal images were binarized into luminal area (LA) and stromal area. CVI was defined as the ratio of LA to total circumscribed choroid area (TCA). Mean choroidal thickness (CT) and mean CVI between glaucoma patients and healthy subjects were compared.
RESULTS
OAG and PPG eyes showed smaller LA (0.45 ± 0.13 ㎟ vs. 0.47 ± 0.11 ㎟, p = 0.04). In multivariate regression analysis, CVI of both OAG (64.34±0.19%, p = 0.001) and PPG (65.37±0.15%, p = 0.001) were significantly lower than healthy eyes (68.81±0.14%).
CONCLUSION
Eyes with glaucoma demonstrated reduced CVI compared with healthy eyes. CVI may be a potential noninvasive tool for studying vascular dysfunction in glaucoma.
摘要
目的
通过脉络膜血管指数（CVI）与健康受试者进行比较，评估青光眼的脉络膜结构变化。
方法
本回顾性研究纳入 56 例开角型青光眼（OAG）患者、50 例前期青光眼（PPG）患者和 50 名年龄匹配的健康对照者。脉络膜图像分为管腔面积（LA）和基质面积。CVI 定义为 LA 与总脉络膜周长面积（TCA）的比值。比较青光眼患者和健康受试者的平均脉络膜厚度（CT）和平均 CVI。
结果
OAG 和 PPG 眼的 LA 较小（0.45±0.13 ㎟比 0.47±0.11 ㎟，p=0.04）。多变量回归分析显示，OAG（64.34±0.19%，p=0.001）和 PPG（65.37±0.15%，p=0.001）的 CVI 均显著低于健康眼（68.81±0.14%）。
结论
与健康眼相比，青光眼眼的 CVI 降低。CVI 可能是研究青光眼血管功能障碍的一种潜在的非侵入性工具。
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