孔源性视网膜脱离相关巨大视网膜裂孔眼术后脉络膜血管生物标志物
Postoperative Choroidal Vascular Biomarkers in Eyes with Rhegmatogenous Retinal Detachment-Related Giant Retinal Tears.
作者信息
Quiroz-Reyes Miguel A, Quiroz-Gonzalez Erick A, Quiroz-Gonzalez Miguel A, Lima-Gomez Virgilio
机构信息
Retina Department of Oftalmologia Integral ABC, Medical and Surgical Assistance Institution (Nonprofit Organization) Affiliated with the Postgraduate Studies Division at the National Autonomous University of Mexico, Av. Paseo de las Palmas 735 Suite 303, Lomas de Chapultepec, 11000, Mexico City, Mexico.
Institute of Ophthalmology. Fundacion Conde de Valenciana, Medical and Surgical Assistance Institution (Nonprofit Organization) Affiliated with the Postgraduate Studies Division at the National Autonomous University of Mexico, Calle Chimalpopoca 14. Col Obrera, 06800, Mexico, Mexico.
出版信息
Int J Retina Vitreous. 2023 Aug 1;9(1):45. doi: 10.1186/s40942-023-00482-9.
PURPOSE
Choroidal vascularity index (CVI) and choriocapillaris flow area (CFA) are perfusion biomarkers relevant to retinal disease management. There is limited knowledge regarding these biomarkers in eyes that have been successfully treated for rhegmatogenous retinal detachment (RRD) due to giant retinal tears (GRTs). This study aimed to analyze the relationship between choroidal perfusion biomarkers and functional outcomes in surgically treated eyes with GRT-associated RRD and their fellow eyes.
METHODS
A total of 33 GRT eyes and 29 fellow eyes were included in this study. All RRD-GRT eyes were treated with vitrectomy and categorized into two groups based on whether additional scleral buckles (SB) were placed. Visual and choroidal features were compared between the groups.
RESULTS
The subjects had an average age of 55.18 years, a mean time of 2.36 weeks before surgery, and a mean follow-up time of 25.9 months. Best-corrected visual acuity (BCVA) was substantially worse in GRT eyes (1.9 logMAR) than in fellow control eyes (0.23 logMAR) but substantially improved after surgery (0.59 logMAR). There were no differences in the presurgical characteristics and BCVA between the eyes that did and did not undergo SB. Long-term CVI and CFA were lower in eyes with GRT than in their fellow eyes. Among eyes with GRT, those with SB had significantly lower CVI and CFA. Correlation analysis revealed that the CVI and CFA were positively correlated with visual outcomes (negative correlation with logMAR).
CONCLUSION
Despite successful surgical repair, long-term functional and choroidal evaluations showed permanent changes in eyes with GRT. Positive correlations between perfusion biomarkers and visual function suggest that better choroidal vasculature is associated with better visual outcomes. The results of this study highlight the benefits of analyzing choroidal vasculature biomarkers and the relationship between the choroidal anatomy and vision.
目的
脉络膜血管指数（CVI）和脉络膜毛细血管血流面积（CFA）是与视网膜疾病管理相关的灌注生物标志物。对于因巨大视网膜裂孔（GRT）导致的孔源性视网膜脱离（RRD）而接受成功治疗的眼睛，关于这些生物标志物的了解有限。本研究旨在分析接受手术治疗的GRT相关RRD眼及其对侧眼的脉络膜灌注生物标志物与功能结局之间的关系。
方法
本研究共纳入33只GRT眼和29只对侧眼。所有RRD-GRT眼均接受玻璃体切除术，并根据是否放置额外的巩膜扣带（SB）分为两组。比较两组之间的视觉和脉络膜特征。
结果
受试者的平均年龄为55.18岁，术前平均时间为2.36周，平均随访时间为25.9个月。GRT眼的最佳矫正视力（BCVA）（1.9 logMAR）明显差于对侧对照眼（0.23 logMAR），但术后明显改善（0.59 logMAR）。接受和未接受SB的眼睛术前特征和BCVA无差异。GRT眼的长期CVI和CFA低于其对侧眼。在GRT眼中，接受SB的眼睛CVI和CFA明显更低。相关性分析显示，CVI和CFA与视觉结局呈正相关（与logMAR呈负相关）。
结论
尽管手术修复成功，但长期功能和脉络膜评估显示GRT眼存在永久性改变。灌注生物标志物与视觉功能之间的正相关表明，更好的脉络膜血管系统与更好的视觉结局相关。本研究结果突出了分析脉络膜血管系统生物标志物的益处以及脉络膜解剖结构与视力之间的关系。
Zotero 插件