Perry P J, Alexander B, Prince R A, Dunner F J
Br J Psychiatry. 1986 Apr;148:401-5. doi: 10.1192/bjp.148.4.401.
Two methods for predicting steady-state serum lithium level were compared prospectively in in-patients suffering from affective disorder. A single-point prospective administration model that required a single 24-hour serum lithium level, following a test dose produced statistically similar predictions of the observed steady-state lithium levels as did a model that required 12- and 36-hour levels. However, the latter two-point method produced significantly more accurate predictions from clinical interpretation. Although the two-point approach is preferable, the single-point method is clinically acceptable if its limitations of accuracy are taken into consideration.
对两种预测情感障碍住院患者稳态血清锂水平的方法进行了前瞻性比较。一种单点前瞻性给药模型，在给予试验剂量后只需单次24小时血清锂水平，与需要12小时和36小时水平的模型相比，对观察到的稳态锂水平产生的统计学预测相似。然而，后一种两点法从临床解释来看能产生显著更准确的预测。虽然两点法更可取，但如果考虑到单点法准确性的局限性，其在临床上也是可以接受的。
