Li Xiao-Yan, Zhang Zi-Chuan
Department of Stomatology, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Department of Stomatology, Bethune International Peace Hospital, Shijiazhuang, China.
J Dent Sci. 2016 Dec;11(4):401-404. doi: 10.1016/j.jds.2016.06.002. Epub 2016 Aug 9.
BACKGROUND/PURPOSE: Recurrent aphthous stomatitis (RAS) is a common oral mucosal disease. Recently, oxidative stress has been thought to play a major role in the etiopathogenesis of RAS. The aim of this investigation was to compare the serum levels of an important oxidant agent [malondialdehyde (MDA)] and nonenzymatic antioxidants [uric acid (UA) and vitamins C and E] in patients with RAS versus healthy individuals.
Ninety-seven patients with idiopathic minor RAS and 97 race-, age-, and sex-matched healthy individuals were included in this study. All these individuals were allocated to three groups: RAS patients in the active stage (Group A); the same RAS patients in Group A in the remission stage (Group B); and healthy individuals without RAS (Group C). The serum levels of MDA, UA, and vitamins C and E were measured by the spectrophotometric method. Independent sample test and paired test were performed for statistical evaluation.
Serum MDA level of Group A was significantly higher than that of Group B (P = 0.040) or Group C (P = 0.011), whereas the serum level of vitamin E was significantly decreased in Group A as compared with Group B (P = 0.012) or Group C (P = 0.001). No statistically significant differences were found between Group B and Group C in terms of MDA, UA, and vitamins C and E serum levels (P > 0.05).
With the double-faced character of oxidant/antioxidant, UA and vitamin C may not play a crucial role in the pathogenesis of RAS. However, MDA and vitamin E can be used as indicators for RAS.
背景/目的：复发性阿弗他口炎（RAS）是一种常见的口腔黏膜疾病。近来，氧化应激被认为在RAS的发病机制中起主要作用。本研究的目的是比较RAS患者与健康个体血清中一种重要氧化剂[丙二醛（MDA）]及非酶抗氧化剂[尿酸（UA）、维生素C和维生素E]的水平。
本研究纳入97例特发性轻型RAS患者及97例种族、年龄和性别相匹配的健康个体。所有个体被分为三组：活动期RAS患者（A组）；A组处于缓解期的同一批RAS患者（B组）；无RAS的健康个体（C组）。采用分光光度法测定血清中MDA、UA及维生素C和维生素E的水平。进行独立样本t检验和配对t检验以进行统计学评估。
A组血清MDA水平显著高于B组（P = 0.040）或C组（P = 0.011），而A组血清维生素E水平与B组（P = 0.012）或C组（P = 0.001）相比显著降低。B组和C组在MDA、UA及维生素C和维生素E血清水平方面未发现统计学显著差异（P > 0.05）。
鉴于氧化剂/抗氧化剂的双重特性，UA和维生素C可能在RAS发病机制中不起关键作用。然而，MDA和维生素E可作为RAS的指标。
