台湾汉族人群中维生素D受体基因多态性与牙周炎的关联
Association of vitamin D receptor gene polymorphisms and periodontitis in a Taiwanese Han population.
作者信息
Ho Ya-Ping, Lin Ying-Chu, Yang Yi-Hsin, Chou Yu-Hsiang, Ho Kun-Yen, Wu Yi-Min, Tsai Chi-Cheng
机构信息
Division of Periodontics, Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
出版信息
J Dent Sci. 2017 Dec;12(4):360-367. doi: 10.1016/j.jds.2017.07.001. Epub 2017 Jul 31.
BACKGROUND/PURPOSE: : Genetic polymorphisms in the vitamin D receptor (VDR) gene are related to the immune response and bone metabolism, both of which are implicated in the pathogenesis of periodontitis. This study was to investigate the association between VDR-gene polymorphisms and periodontitis among a Taiwanese Han ethnic population.
MATERIALS AND METHODS
Ninety-two aggressive periodontitis (AgP), 385 chronic periodontitis (CP) and 163 healthy controls (HC) were recruited from dental clinics. Demographic characteristics and possible confounding factors were obtained using a self-reported questionnaire. The VDR rs731236 (I), rs7975232 (I), rs1544410 (I), and rs2228570 (I) polymorphisms were genotyped using PCR-RFLP methods. Statistical analyses were applied to determine the associations.
RESULTS
The individual VDR polymorphisms were not associated with risk of AgP and CP. The f allele of rs2228570 was related to decreased risk for AgP. Subjects with TAbF (adjusted OR = 7.2, 95% CI = 3.2-7.2, p < 0.0001) or TAbf (adjusted OR = 0.17, 95% CI = 0.05-0.48, p = 0.002) combined polymorphisms were significantly associated with AgP. Subjects with Tabf (adjusted OR = 2.6, 95% CI = 1.8-3.8, p < 0.0001), TAbF (adjusted OR = 4.4, 95% CI = 2.6-8.1, p < 0.0001), TabF (adjusted OR = 0.36, 95% CI = 0.2-0.5, p < 0.0001), or TAbf (adjusted OR = 0.45, 95% CI = 0.3-0.7, p = 0.001) combined polymorphisms were significantly associated with CP.
CONCLUSION
The study indicates that VDR gene polymorphisms are associated with AgP and CP in a Taiwanese Han population.
背景/目的：维生素D受体（VDR）基因的遗传多态性与免疫反应和骨代谢相关，而这两者均与牙周炎的发病机制有关。本研究旨在调查台湾汉族人群中VDR基因多态性与牙周炎之间的关联。
材料与方法
从牙科诊所招募了92例侵袭性牙周炎（AgP）患者、385例慢性牙周炎（CP）患者和163例健康对照（HC）。通过自我报告问卷获取人口统计学特征和可能的混杂因素。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法对VDR基因rs731236（I）、rs7975232（I）、rs1544410（I）和rs2228570（I）多态性进行基因分型。应用统计学分析确定关联。
结果
单个VDR基因多态性与AgP和CP的风险无关。rs2228570的f等位基因与AgP风险降低相关。具有TAbF（校正比值比[OR]=7.2，95%可信区间[CI]=3.2-7.2，p<0.0001）或TAbf（校正OR=0.17，95%CI=0.05-0.48，p=0.002）联合多态性的受试者与AgP显著相关。具有Tabf（校正OR=2.6，95%CI=1.8-3.8，p<0.0001）、TAbF（校正OR=4.4，95%CI=2.6-8.1，p<0.0001）、TabF（校正OR=0.36，95%CI=0.2-0.5，p<0.0001）或TAbf（校正OR=0.45，95%CI=0.3-0.7，p=0.001）联合多态性的受试者与CP显著相关。
结论
该研究表明，在台湾汉族人群中，VDR基因多态性与AgP和CP相关。
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