School of Public Health, Shandong University, Jinan, China.
J Periodontol. 2012 Sep;83(9):1095-103. doi: 10.1902/jop.2011.110518. Epub 2011 Dec 19.
The purpose of the meta-analysis is to explore the association between vitamin D receptor polymorphisms (including four gene loci: Taq-I, Bsm-I, Apa-I, and Fok-I) for susceptibility to periodontitis (either chronic [CP] or aggressive [AP]). Up to now, there has been only one systematic review focusing on this topic. We obtained some different findings compared with the previously published literature.
Nineteen case-control studies were identified through a search of multiple electronic databases (from January 1, 1999 to June 30, 2011). The pooled odds ratios (ORs) and 95% confidence intervals (CIs) using codominant, dominant, and recessive genetic models from meta-analysis were the main outcome measure. The Harbord test was used to detect the publication bias for each group.
Eighteen identified articles met the eligibility criteria. Through overall analyses, no statistical association was found between polymorphisms of the four gene loci and periodontitis. However, based on subgroup analyses, a significant association between the Taq-I variants and CP rather than AP was shown in Asians (OR = 0.590; 95% CI = 0.425, 0.818) but not in whites (OR = 0.823; 95% CI = 0.637, 1.063). No statistically significant association was found between polymorphisms of Bsm-I and Apa-I with either AP or CP. The Fok-I polymorphism showed a statistical association with AP (OR = 1.583; 95% CI = 1.157, 2.166) instead of CP (OR = 1.081; 95% CI = 0.638, 1.830) in Asians.
The results of the present meta-analysis indicate the following: 1) the mutant allele t of the Taq-I locus may be a protective factor for CP but not for AP in Asians, although this was not true in whites; 2) the mutant allele F of the Fok-I locus appeared to be a risk factor for AP rather than CP in Asians; and 3) Bsm-I and Apa-I polymorphisms were found to have no significant associations with susceptibility to periodontitis (CP/AP).
本次荟萃分析的目的是探讨维生素 D 受体多态性（包括 Taq-I、Bsm-I、Apa-I 和 Fok-I 四个基因座）与牙周炎（慢性[CP]或侵袭性[AP]）易感性之间的关联。到目前为止，仅有一项针对这一主题的系统综述。我们获得了一些与之前发表的文献不同的发现。
通过对多个电子数据库（1999 年 1 月 1 日至 2011 年 6 月 30 日）的检索，共确定了 19 项病例对照研究。使用荟萃分析的共显性、显性和隐性遗传模型得出的合并优势比（OR）和 95%置信区间（CI）是主要的观察指标。使用 Harbord 检验检测各组的发表偏倚。
18 篇符合入选标准的文章被识别。通过总体分析，未发现四个基因座的多态性与牙周炎之间存在统计学关联。然而，基于亚组分析，在亚洲人群中，Taq-I 变体与 CP 而非 AP 之间存在显著关联（OR=0.590；95%CI=0.425，0.818），但在白人中无统计学关联（OR=0.823；95%CI=0.637，1.063）。Bsm-I 和 Apa-I 多态性与 AP 或 CP 均无统计学关联。Fok-I 多态性与 AP（OR=1.583；95%CI=1.157，2.166）而不是 CP（OR=1.081；95%CI=0.638，1.830）在亚洲人群中存在统计学关联。
本次荟萃分析的结果表明：1）Taq-I 基因座的突变等位基因 t 可能是 CP 的保护因素，但不是 AP 的保护因素，而在白人中并非如此；2）Fok-I 基因座的突变等位基因 F 似乎是 AP 的危险因素，而不是 CP 的危险因素，在亚洲人群中；3）Bsm-I 和 Apa-I 多态性与牙周炎（CP/AP）易感性无显著关联。
