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在骨骼成熟大鼠的颅骨缺损模型中，乙酰甘露聚糖增加了骨表面、骨体积和骨密度。

Acemannan increased bone surface, bone volume, and bone density in a calvarial defect model in skeletally-mature rats.

作者信息

Godoy Dyna Jeanne D, Chokboribal Jaroenporn, Pauwels Ruben, Banlunara Wijit, Sangvanich Polkit, Jaroenporn Sukanya, Thunyakitpisal Pasutha

机构信息

Dental Biomaterials Science Program, Graduate School, Chulalongkorn University, Bangkok, Thailand.

Department of Materials Science, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.

出版信息

J Dent Sci. 2018 Dec;13(4):334-341. doi: 10.1016/j.jds.2018.06.004. Epub 2018 Jul 20.

DOI:10.1016/j.jds.2018.06.004
PMID:30895142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6388811/
Abstract

BACKGROUND/PURPOSE: Acemannan, a β-(1-4)-acetylated polymannose extracted from gel, has been proposed as biomaterial for bone regeneration. The aim of this study was to investigate the effect of acemannan in calvarial defect healing.

MATERIALS AND METHODS

Acemannan was processed to freeze-dried sponge form and disinfected by UV irradiation. Thirty-five female Sprague-Dawley rats were used in the study. Seven-mm diameter mid-calvarial defects were created and randomly allocated into blood clot control (C), acemannan 1 mg (A1), 2 mg (A2), 4 mg (A4), and 8 mg (A8) groups (n = 7). After four weeks, the calvarial specimens were subjected to microcomputed tomography (microCT) and histopathological analysis.

RESULTS

MicroCT revealed a significant increase in bone surface and bone volume in the A1 and A2 groups, and tissue mineral density in the A4 and A8 groups compared with the control group ( < 0.05). Histologically, the acemannan-treated groups had denser bone matrix compared with the control group.

CONCLUSION

Acemannan is an effective bioactive agent for bone regeneration, enhancing bone growth as assayed in two- and three-dimensions.

摘要

背景/目的：乙酰甘露聚糖是一种从凝胶中提取的β-(1-4)-乙酰化多聚甘露糖，已被提议作为骨再生的生物材料。本研究的目的是探讨乙酰甘露聚糖在颅骨缺损愈合中的作用。

材料与方法

将乙酰甘露聚糖加工成冻干海绵形式，并通过紫外线照射进行消毒。本研究使用了35只雌性Sprague-Dawley大鼠。制作直径7毫米的颅骨中部缺损，并将其随机分为血凝块对照组（C）、1毫克乙酰甘露聚糖组（A1）、2毫克乙酰甘露聚糖组（A2）、4毫克乙酰甘露聚糖组（A4）和8毫克乙酰甘露聚糖组（A8）（每组n = 7）。四周后，对颅骨标本进行微计算机断层扫描（microCT）和组织病理学分析。

结果

与对照组相比，MicroCT显示A1组和A2组的骨表面和骨体积显著增加，A4组和A8组的组织矿物质密度显著增加（P < 0.05）。组织学上，与对照组相比，乙酰甘露聚糖处理组的骨基质更致密。

结论

乙酰甘露聚糖是一种有效的骨再生生物活性剂，在二维和三维检测中均可促进骨生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da1/6388811/1045f69a9932/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da1/6388811/1fb22c6af34c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da1/6388811/9515277adcb3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da1/6388811/0ca1da55bb07/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da1/6388811/508966d83fca/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da1/6388811/1045f69a9932/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da1/6388811/1fb22c6af34c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da1/6388811/9515277adcb3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da1/6388811/0ca1da55bb07/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da1/6388811/508966d83fca/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da1/6388811/1045f69a9932/gr5.jpg

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