1 Endocrinology and Nutrition Unit, Segovia General Hospital, Segovia, Spain.
2 Insulcloud S.L. (B87131454), Madrid, Spain.
Diabetes Technol Ther. 2019 Apr;21(4):209-214. doi: 10.1089/dia.2018.0361. Epub 2019 Mar 21.
Achieving and maintaining controlled glycemic levels are challenging in people with insulin-treated diabetes mellitus, suboptimal insulin injections being the main obstacle to treatment success.
This research article presents the main functionalities and performance tests on Insulclock, an electronic device plugged into insulin pens and connected with a smartphone app to improve insulin management. Insulclock tracks the date, time of day, dose, type of insulin, temperature, and duration of insulin injections. Information is stored in the device memory and is available for analysis by patients and health care providers. Insulclock device also has a reminder system with visual and acoustic alerts to reduce insulin omissions and mistiming.
The main performance tests reveal that Insulclock can detect seven types of insulin pens with a 97% correct classification rate. Among 556 injections, most of the doses were accurately detected (deviation = 0), with relative errors ranging from 3% to 7% across different dosages. The duration of injections recorded by this device strongly correlated with that detected by an external chronometer (R = 0.99, root-mean-square deviation [RMSD] = 0.39). Moreover, the precision of the temperature sensor was evidenced by high correlation of temperatures detected by Insulclock and by an external thermometer (Pearson's R = 0.90, RMSD = 0.45).
Insulclock is a novel device capable of tracking dosing, timing, and missing insulin injections. The promising capabilities it offers for diabetes mellitus self-management may help health care providers, researchers, and insulin users avoid frequent errors in insulin administration.
对于接受胰岛素治疗的糖尿病患者来说，实现并维持血糖控制水平具有挑战性，而胰岛素注射不规范是治疗成功的主要障碍。
本研究文章介绍了电子设备 Insulclock 的主要功能和性能测试，该设备可插入胰岛素笔并与智能手机应用程序连接，以改善胰岛素管理。Insulclock 可跟踪日期、时间、剂量、胰岛素类型、温度和胰岛素注射持续时间。信息存储在设备内存中，可供患者和医疗保健提供者分析。Insulclock 设备还具有提醒系统，包括视觉和听觉警报，以减少胰岛素遗漏和时间错误。
主要性能测试表明，Insulclock 可以检测七种类型的胰岛素笔，分类准确率为 97%。在 556 次注射中，大多数剂量都被准确检测到（偏差=0），不同剂量的相对误差在 3%至 7%之间。该设备记录的注射持续时间与外部计时器检测到的时间高度相关（R=0.99，均方根偏差[RMSD]=0.39）。此外，Insulclock 检测到的温度与外部温度计检测到的温度高度相关，证明了温度传感器的精度（Pearson's R=0.90，RMSD=0.45）。
Insulclock 是一种能够跟踪剂量、时间和遗漏胰岛素注射的新型设备。它在糖尿病自我管理方面具有广阔的应用前景，可能有助于医疗保健提供者、研究人员和胰岛素使用者避免胰岛素给药过程中的常见错误。
