Osato K, Tsugami H, Harada K, Maruyama J
Genitourin Med. 1986 Jun;62(3):158-62. doi: 10.1136/sti.62.3.158.
During the three years 1981-3, 134 (9.1%) of 1473 patients presenting at our clinics were found to be infected with penicillinase producing strains of Neisseria gonorrhoeae (PPNG). Minimum inhibitory concentrations (MICs) of benzylpenicillin and ampicillin against these PPNG strains were 8 mg/l or more, whereas against non-PPNG strains they were consistently 4 mg/l or less. In contrast, the MIC of BRL25000 (two parts amoxycillin and one part clavulanic acid, the beta lactamase inhibitor) was 4 mg/l or less even against PPNG strains. MICs of a number of other drugs commonly used to treat gonorrhoea, such as cephaloridine, cefoxitin, tetracycline, doxycycline, minocycline, kanamycin, and spectinomycin, showed no appreciable differences between non-PPNG and PPNG strains and the MIC of cephaloridine in particular was relatively high. BRL25000 proved to be very effective in the treatment of PPNG infection and cured all of 121 patients treated. A daily dose of 2.25g, cured 105 patients in two days, 11 patients in three days, four patients in four days, and one patient in five days. A new rapid diagnostic method for detecting PPNG strains, capable of application at an outpatient clinic and providing a result on the following day, is described.
在1981年至1983年的三年间，在我们诊所就诊的1473名患者中，有134名（9.1%）被发现感染了产青霉素酶的淋病奈瑟菌（PPNG）。苄青霉素和氨苄青霉素对这些PPNG菌株的最低抑菌浓度（MIC）为8mg/l或更高，而对非PPNG菌株，其MIC始终为4mg/l或更低。相比之下，BRL25000（两份阿莫西林和一份克拉维酸，β-内酰胺酶抑制剂）的MIC即使对PPNG菌株也为4mg/l或更低。许多其他常用于治疗淋病的药物，如头孢菌素、头孢西丁、四环素、强力霉素、米诺环素、卡那霉素和壮观霉素，其MIC在非PPNG菌株和PPNG菌株之间没有明显差异，尤其是头孢菌素的MIC相对较高。事实证明，BRL25000在治疗PPNG感染方面非常有效，治愈了所有接受治疗的121名患者。每日剂量为2.25g，在两天内治愈了105名患者，三天内治愈了11名患者，四天内治愈了4名患者，五天内治愈了1名患者。本文描述了一种新的快速诊断方法，用于检测PPNG菌株，该方法可在门诊应用，并在第二天得出结果。
