棒酸对淋病奈瑟菌中β-内酰胺酶的抑制作用。
Inhibition of beta-lactamase in Neisseria gonorrhoeae by sodium clavulanate.
作者信息
Miller J M, Baker C N, Thornsberry C
出版信息
Antimicrob Agents Chemother. 1978 Nov;14(5):794-6. doi: 10.1128/AAC.14.5.794.
Abstract
Sodium clavulanate at subinhibitory concentrations affected the activity of penicillin G, ampicillin, or amoxicillin on beta-lactamase-positive strains of Neisseria gonorrhoeae as demonstrated by marked reduction in the minimal inhibitory concentrations of the drugs for the organisms. The compound did not affect the activity of these penicillins on beta-lactamase-negative strains of N. gonorrhoeae. It also had no effect on the activity of cefoxitin against either beta-lactamase-negative or -positive strains. The reduction in minimal inhibitory concentrations of the penicillins for the beta-lactamase-positive organisms brought about by sodium clavulanate is probably due to inhibition of the beta-lactamase by the compound.
摘要
在亚抑菌浓度下，克拉维酸钠会影响青霉素G、氨苄西林或阿莫西林对淋病奈瑟菌β-内酰胺酶阳性菌株的活性，这可通过这些药物对该菌的最低抑菌浓度显著降低得以证明。该化合物对这些青霉素对淋病奈瑟菌β-内酰胺酶阴性菌株的活性没有影响。它对头孢西丁对β-内酰胺酶阴性或阳性菌株的活性也没有影响。克拉维酸钠使青霉素对β-内酰胺酶阳性菌的最低抑菌浓度降低，可能是由于该化合物对β-内酰胺酶的抑制作用。
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