Tapsall J W, Phillips E A, Morris L M
Department of Microbiology, Prince of Wales Hospital, Randwick, Sydney, New South Wales, Australia.
Genitourin Med. 1987 Oct;63(5):305-8. doi: 10.1136/sti.63.5.305.
Single dose Augmentin treatment fails to cure an appreciable proportion of patients infected with penicillinase producing Neisseria gonorrhoeae (PPNG) strains in parts of the world where high levels of chromosomally mediated intrinsic resistance are also present in gonococci. The levels of intrinsic resistance to penicillin of 31 PPNG strains isolated in Sydney were assessed by obtaining beta lactamase negative variants of these strains and measuring the minimum inhibitory concentration of penicillin by agar plate dilution techniques. The levels of intrinsic resistance found in these imported PPNG strains were higher than those recorded for local isolates of non-PPNG strains, which indicates that caution should be exercised in the use of single dose Augmentin treatment of infections with PPNG strains in Sydney.
在世界上一些地区，淋病奈瑟菌（PPNG）菌株产生青霉素酶，同时淋球菌中也存在高水平的染色体介导的固有耐药性，单剂量阿莫西林治疗无法治愈相当一部分感染此类菌株的患者。通过获得悉尼分离出的31株PPNG菌株的β-内酰胺酶阴性变体，并采用琼脂平板稀释技术测量青霉素的最低抑菌浓度，评估了这些菌株对青霉素的固有耐药水平。在这些输入的PPNG菌株中发现的固有耐药水平高于非PPNG菌株本地分离株的记录水平，这表明在悉尼使用单剂量阿莫西林治疗PPNG菌株感染时应谨慎。
