头孢哌酮（头孢必）用于治疗由产青霉素酶的淋病奈瑟菌引起淋病的男性患者。
Cefoperazone (Cefobid) for treating men with gonorrhoea caused by penicillinase producing Neisseria gonorrhoeae.
作者信息
Kim J H, Ro Y S, Kim Y T
出版信息
Br J Vener Dis. 1984 Aug;60(4):238-40. doi: 10.1136/sti.60.4.238.
Abstract
The recent emergence of spectinomycin resistant penicillinase producing Neisseria gonorrhoeae (PPNG) and the high prevalence of PPNG strains among the gonococcal isolates in Seoul represent a grave challenge to the programme for controlling sexually transmitted disease (STD). Fifty men with uncomplicated gonococcal urethritis caused by PPNG strains were treated with a single intramuscular injection of 1 g cefoperazone. Forty two patients were followed up. All patients recovered including three who became reinfected and required further treatment. Two patients (4.8%) developed postgonococcal urethritis (PGU). The MIC90 of cefoperazone measured by an agar dilution susceptibility test was 0.12 mg/l.
摘要
近期出现的对壮观霉素耐药的产青霉素酶淋病奈瑟菌（PPNG）以及首尔淋病菌株中PPNG菌株的高流行率，对性传播疾病（STD）控制计划构成了严峻挑战。50例由PPNG菌株引起的无并发症淋菌性尿道炎男性患者接受了单次1g头孢哌酮肌肉注射治疗。对42例患者进行了随访。所有患者均康复，包括3例再次感染并需要进一步治疗的患者。2例患者（4.8%）发生了淋菌性尿道炎后尿道炎（PGU）。通过琼脂稀释药敏试验测得头孢哌酮的MIC90为0.12mg/l。
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