Liu Baosong, Bai Ming, Peng Mengfan, Miao Mingsan
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Saudi J Biol Sci. 2019 Mar;26(3):577-581. doi: 10.1016/j.sjbs.2018.11.018. Epub 2018 Nov 26.
Observe anti-inflammatory effect and the effect on acute pharyngitis rats model induced by ammonia water of compound Lobelia oral liquid, providing experimental basis for its clinical use.
Use egg white establish foot swelling rats model and use carboxymethyl cellulose establish white blood cell migration rats model. Then observe the anti-inflammatory effect of compound Lobelia oral liquid. Use 15% ammonia spray at pharyngeal establish acute pharyngitis rats model, Visual observation and conduct grading of pharyngeal tissue stimulation in rats, measure the levels of TNF-α and IL-6 in serum. Pharyngeal tissue was taken to observe the morphological changes.
All dose groups of compound Lobelia oral liquid can reduce the rate of foot swelling of rats at all time points ( < 0.01 or < 0.05), and significantly reduce the number of white blood cells of rats ( < 0.01); And improve the local hyperemia degree, reduce secretion, reduce local swelling of pharyngeal tissue, reduce the serum TNF-α and IL-6 levels of acute pharyngitis rats with different degrees ( < 0.01 or < 0.05).
Compound Lobelia oral liquid has a good anti-inflammatory effect on foot swelling and white blood cell migration rats model, as well as significant improvement effect on acute pharyngitis rats model.
观察复方半边莲口服液的抗炎作用及其对氨水致大鼠急性咽炎模型的影响，为其临床应用提供实验依据。
用蛋清建立大鼠足肿胀模型，用羧甲基纤维素建立大鼠白细胞游走模型，观察复方半边莲口服液的抗炎作用。用15%氨水喷雾大鼠咽部建立急性咽炎模型，肉眼观察并对大鼠咽部组织刺激进行评分，检测血清中TNF-α和IL-6水平，取咽部组织观察形态学变化。
复方半边莲口服液各剂量组在各时间点均能降低大鼠足肿胀率（<0.01或<0.05），并显著减少大鼠白细胞数（<0.01）；且能改善咽部组织局部充血程度，减少分泌物，减轻局部肿胀，不同程度降低急性咽炎大鼠血清TNF-α和IL-6水平（<0.01或<0.05）。
复方半边莲口服液对大鼠足肿胀和白细胞游走模型有良好的抗炎作用，对急性咽炎大鼠模型有显著改善作用。
