• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

TERT promoter mutations in melanoma survival.

作者信息

Nagore Eduardo, Rachakonda Sivaramakrishna, Kumar Rajiv

机构信息

Department of Dermatology, Instituto Valenciano de Oncologia, Valencia, Spain; School of Medicine, Universidad Catolica da Valenciana "San Vincent Martir", Valencia, Spain.

Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany; Consortium for Translational Research, German Cancer Research Center, Heidelberg, Germany.

出版信息

Oncotarget. 2019 Feb 22;10(16):1546-1548. doi: 10.18632/oncotarget.26688.

DOI:10.18632/oncotarget.26688
PMID:30899422
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6422178/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea6/6422178/55b8f37d7ba5/oncotarget-10-1546-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea6/6422178/55b8f37d7ba5/oncotarget-10-1546-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea6/6422178/55b8f37d7ba5/oncotarget-10-1546-g001.jpg

相似文献

1
TERT promoter mutations in melanoma survival.黑色素瘤生存中的端粒酶逆转录酶（TERT）启动子突变
Oncotarget. 2019 Feb 22;10(16):1546-1548. doi: 10.18632/oncotarget.26688.
2
Distribution of TERT promoter mutations in primary and metastatic melanomas in Austrian patients.奥地利患者原发性和转移性黑色素瘤中TERT启动子突变的分布情况。
J Cancer Res Clin Oncol. 2017 Apr;143(4):613-617. doi: 10.1007/s00432-016-2322-1. Epub 2016 Dec 18.
3
Pathway and Promoter Gene Mutation Pattern and Its Prognostic Value in Melanoma Patients: A Retrospective Study of 2,793 Cases.黑色素瘤患者的通路和启动子基因突变模式及其预后价值：一项回顾性研究 2793 例。
Clin Cancer Res. 2017 Oct 15;23(20):6120-6127. doi: 10.1158/1078-0432.CCR-17-0980. Epub 2017 Jul 18.
4
Genetic and Epigenetic Alterations of TERT Are Associated with Inferior Outcome in Adolescent and Young Adult Patients with Melanoma.TERT 的遗传和表观遗传改变与青少年和年轻成年黑色素瘤患者的不良预后相关。
Sci Rep. 2017 Apr 5;7:45704. doi: 10.1038/srep45704.
5
Coexistence of TERT promoter and BRAF mutations in cutaneous melanoma is associated with more clinicopathological features of aggressiveness.皮肤黑色素瘤中TERT启动子与BRAF突变共存与更多侵袭性临床病理特征相关。
Virchows Arch. 2015 Aug;467(2):177-84. doi: 10.1007/s00428-015-1784-x. Epub 2015 Jun 9.
6
Prognostic impact and concordance of TERT promoter mutation and protein expression in matched primary and metastatic cutaneous melanoma.TERT 启动子突变与蛋白表达在配对原发和转移性皮肤黑色素瘤中的预后影响及一致性。
Br J Cancer. 2018 Jan;118(1):98-105. doi: 10.1038/bjc.2017.384. Epub 2017 Nov 9.
7
Prevalence and implications of TERT promoter mutation in uveal and conjunctival melanoma and in benign and premalignant conjunctival melanocytic lesions.葡萄膜和结膜黑色素瘤以及良性和癌前结膜黑素细胞病变中TERT启动子突变的患病率及其影响
Invest Ophthalmol Vis Sci. 2014 Aug 26;55(9):6024-30. doi: 10.1167/iovs.14-14901.
8
Melanomas of unknown primary frequently harbor TERT-promoter mutations.不明原发灶的黑色素瘤常携带 TERT 启动子突变。
Melanoma Res. 2014 Apr;24(2):131-6. doi: 10.1097/CMR.0000000000000048.
9
TERT promoter mutations in melanoma render TERT expression dependent on MAPK pathway activation.黑色素瘤中的端粒酶逆转录酶（TERT）启动子突变使TERT表达依赖于丝裂原活化蛋白激酶（MAPK）信号通路的激活。
Oncotarget. 2016 Aug 16;7(33):53127-53136. doi: 10.18632/oncotarget.10634.
10
Molecular profiling, including TERT promoter mutations, of acral lentiginous melanomas.肢端雀斑样痣黑色素瘤的分子特征分析，包括端粒酶逆转录酶（TERT）启动子突变。
Melanoma Res. 2016 Apr;26(2):93-9. doi: 10.1097/CMR.0000000000000222.

引用本文的文献

1
DNA Methylation Array Analysis Identifies Biological Subgroups of Cutaneous Melanoma and Reveals Extensive Differences with Benign Melanocytic Nevi.DNA甲基化阵列分析鉴定皮肤黑色素瘤的生物学亚组并揭示与良性黑素细胞痣的广泛差异。
Diagnostics (Basel). 2025 Feb 21;15(5):531. doi: 10.3390/diagnostics15050531.
2
Genomic landscape of malignant phyllodes tumors reveals multiple targetable opportunities.恶性叶状肿瘤的基因组图谱揭示了多个可靶向的机会。
Oncologist. 2024 Dec 6;29(12):1024-1031. doi: 10.1093/oncolo/oyae218.
3
Using deep learning to decipher the impact of telomerase promoter mutations on the dynamic metastatic morpholome.

本文引用的文献

1
Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner.β1L 异构体的 GABP 破坏以 TERT 启动子突变依赖性方式逆转胶质母细胞瘤复制性永生。
Cancer Cell. 2018 Sep 10;34(3):513-528.e8. doi: 10.1016/j.ccell.2018.08.003.
2
Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1.通过 p52 和 ETS1 的协同结合重新激活突变 TERT 启动子的结构基础。
Nat Commun. 2018 Aug 9;9(1):3183. doi: 10.1038/s41467-018-05644-0.
3
TERT promoter mutation subtypes and survival in stage I and II melanoma patients.
利用深度学习破解端粒酶启动子突变对动态转移性形态的影响。
PLoS Comput Biol. 2024 Jul 30;20(7):e1012271. doi: 10.1371/journal.pcbi.1012271. eCollection 2024 Jul.
4
Clinicopathological and Prognostic Values of Telomerase Reverse Transcriptase () Promoter Mutations in Ovarian Clear Cell Carcinoma for Predicting Tumor Recurrence, Platinum Resistance and Survival.端粒酶逆转录酶（）启动子突变在预测卵巢透明细胞癌肿瘤复发、铂类耐药和生存中的临床病理和预后价值。
Cancer Genomics Proteomics. 2023 Nov-Dec;20(6):626-636. doi: 10.21873/cgp.20411.
5
CTNNB1 mutations, TERT polymorphism and CD8+ cell densities in resected hepatocellular carcinoma are associated with longer time to recurrence.在切除的肝细胞癌中，CTNNB1 突变、TERT 多态性和 CD8+ 细胞密度与更长的无复发生存时间相关。
BMC Cancer. 2022 Aug 13;22(1):884. doi: 10.1186/s12885-022-09989-0.
6
3D Bioprinting: An Enabling Technology to Understand Melanoma.3D生物打印：一种助力理解黑色素瘤的使能技术。
Cancers (Basel). 2022 Jul 20;14(14):3535. doi: 10.3390/cancers14143535.
7
Mutational Characterization of Cutaneous Melanoma Supports Divergent Pathways Model for Melanoma Development.皮肤黑色素瘤的突变特征支持黑色素瘤发展的不同途径模型。
Cancers (Basel). 2021 Oct 18;13(20):5219. doi: 10.3390/cancers13205219.
8
Precision Medicine and Melanoma: Multi-Omics Approaches to Monitoring the Immunotherapy Response.精准医学与黑色素瘤：监测免疫治疗反应的多组学方法
Int J Mol Sci. 2021 Apr 7;22(8):3837. doi: 10.3390/ijms22083837.
9
Non-BRAF Mutant Melanoma: Molecular Features and Therapeutical Implications.非BRAF突变型黑色素瘤：分子特征与治疗意义
Front Mol Biosci. 2020 Jul 24;7:172. doi: 10.3389/fmolb.2020.00172. eCollection 2020.
10
Promoter Mutation as an Independent Prognostic Marker for Poor Prognosis MAPK Inhibitors-Treated Melanoma.启动子突变作为丝裂原活化蛋白激酶（MAPK）抑制剂治疗黑色素瘤预后不良的独立预后标志物。
Cancers (Basel). 2020 Aug 9;12(8):2224. doi: 10.3390/cancers12082224.
TERT 启动子突变亚型与Ⅰ期和Ⅱ期黑色素瘤患者的生存。
Int J Cancer. 2019 Mar 1;144(5):1027-1036. doi: 10.1002/ijc.31780. Epub 2018 Oct 4.
4
Mutations in the promoter of the telomerase gene contribute to tumorigenesis by a two-step mechanism.端粒酶基因启动子中的突变通过两步机制促进肿瘤发生。
Science. 2017 Sep 29;357(6358):1416-1420. doi: 10.1126/science.aao0535. Epub 2017 Aug 17.
5
TERT promoter mutations in telomere biology.端粒生物学中的 TERT 启动子突变。
Mutat Res Rev Mutat Res. 2017 Jan-Mar;771:15-31. doi: 10.1016/j.mrrev.2016.11.002. Epub 2016 Nov 23.
6
TERT promoter mutations in melanoma survival.黑色素瘤生存中的端粒酶逆转录酶（TERT）启动子突变
Int J Cancer. 2016 Jul 1;139(1):75-84. doi: 10.1002/ijc.30042. Epub 2016 Mar 2.
7
Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.端粒酶逆转录酶（TERT）启动子突变、向活性染色质转变以及多种癌症中的单等位基因TERT表达
Genes Dev. 2015 Nov 1;29(21):2219-24. doi: 10.1101/gad.269498.115. Epub 2015 Oct 29.
8
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.TERT 启动子突变在神经胶质瘤和一小部分源自自我更新率低的细胞的肿瘤中频繁发生。
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6021-6. doi: 10.1073/pnas.1303607110. Epub 2013 Mar 25.
9
TERT promoter mutations in familial and sporadic melanoma.TERT 启动子突变与家族性和散发性黑色素瘤。
Science. 2013 Feb 22;339(6122):959-61. doi: 10.1126/science.1230062. Epub 2013 Jan 24.